Regularly methylated novel pro-apoptotic genes associated with recurrence in transitional cell carcinoma of the bladder

International Journal of Cancer. Journal International Du Cancer
Frank ChristophMark Schrader

Abstract

Epigenetic silencing of tumor suppressor genes by promoter hypermethylation has been shown for a variety of genes in bladder cancer. Various p53 target genes have been investigated, but only few demonstrated promoter hypermethylation when semiquantitative detection methods were applied. To address to the question whether promoter methylation of novel p53 effector genes is a common event in transitional cell carcinoma of the bladder, we selected the p53 target genes apoptotic protein-activating factor (APAF-1), Caspase 8 (CASP-8), death-associated protein kinase, (DAPK-1) and insulin-like growth-factor-binding protein-3 (IGFBP-3), performing quantitative methylation-specific real-time PCR. The individual level of methylation (normalized index of methylation) was correlated with clinicopathological features as well as the biological behavior of the superficial and muscleinvasive tumors. Tissue was obtained from 110 tumor patients and 20 patients without urological malignancy. The median follow-up of the tumor patients was 52 months. Hypermethylation of the promoter region in tumor specimens was common for APAF-1 (100%), DAPK-1 (74%) and IGFBP-3 (66%), but not for CASP-8 (3.6%). It was seen less frequently and with undetectable or...Continue Reading

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Citations

Dec 13, 2006·Journal of Cancer Research and Clinical Oncology·Frank ChristophKurt Miller
Aug 16, 2008·International Journal of Clinical Oncology·Hideki Enokida, Masayuki Nakagawa
Aug 4, 2007·Pharmaceutical Research·Marcello D'AmelioFrancesco Cecconi
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