Regulated Cell Death Seen through the Lens of Islet Transplantation

Cell Transplantation
Antonio BruniA M James Shapiro

Abstract

Clinical islet transplantation effectively restores euglycemia and corrects glycosylated hemoglobin in labile type 1 diabetes mellitus (T1DM). Despite marked improvements in islet transplantation outcomes, acute islet cell death remains a substantial obstacle that compromises long-term engraftment outcomes. Multiple organ donors are routinely required to achieve insulin independence. Therapeutic agents that ameliorate cell death and/or control injury-related inflammatory cascades offer potential to improve islet transplant success. Apoptotic cell death has been identified as a major contributor to cellular demise and therapeutic strategies that subvert initiation and consequences of apoptotic cell death have shown promise in pre-clinical models. Indeed, in numerous pathologies and diseases apoptosis has been the most extensively described form of regulated cell death. However, recent identification of novel, alternative regulated cell death pathways in other disease states and solid organ transplantation suggest that these additional pathways may also have substantial relevance in islet transplantation. These regulated, non-apoptotic cell death pathways exhibit distinct biochemical characteristics but have yet to be fully chara...Continue Reading

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Citations

Mar 15, 2020·Xenotransplantation·Angela M Chen, Christopher Burlak
Jul 3, 2020·Frontiers in Pharmacology·Qing YaoLongfa Kou
May 8, 2020·Molecular Medicine Reports·Chunyan WangZhongjun Zhang
Sep 27, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Gyuri KimJae Hyeon Kim
Jun 3, 2021·International Journal of Molecular Sciences·Safia CostesMagalie A Ravier
Jun 18, 2021·Nature Reviews. Endocrinology·Wulf TonnusAndreas Linkermann
Jul 27, 2021·Frontiers in Cell and Developmental Biology·Jia-Yue DuanLing-Qing Yuan
Feb 21, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Maryam KavianiMohammad Hossein Ghahremani

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