Regulated chemokine gene expression in mouse mesothelioma and mesothelial cells: TNF-α upregulates both CC and CXC chemokine genes

Oncology Reports
Simon A FoxMichael J Garlepp

Abstract

Many cancers express an array of chemokines which have the capacity to modulate the nature and function of intratumoural leukocyte infiltrates. In malignant mesothelioma (MM) neither the chemokine signalling networks nor their regulation have been investigated despite the prominence of leucocytic infiltrates in both clinical and experimental tumours. In this study, we examined constitutive and cytokine-regulated expression of CC and CXC chemokine genes in mesothelioma and mesothelial cell cultures derived from two different mouse strains (BALB/C and CBA/CaH). In mouse MM and mesothelial cells MCP-1/JE, GRO-α/KC and RANTES were expressed whereas MIP-1α and MIP-2 were infrequently expressed. Comparison of basal chemokine expression showed that GRO-α/KC mRNA was overexpressed in the malignant cells whereas MCP-1 gene expression and release was downregulated. Treatment of mesothelioma cells with IL-4, IFN-γ or TNF-α revealed that chemokine genes could be more responsive to cytokines in the malignant compared to their mesothelial cells. TNF-α was consistently the most potent positive regulator of both CC and CXC chemokine expression and MCP-1 release. The present study for the first time provides a mechanistic insight into the diffe...Continue Reading

References

Dec 2, 1992·International Journal of Cancer. Journal International Du Cancer·M R DavisB W Robinson
Aug 1, 1997·Immunology and Cell Biology·C C LeongM J Garlepp
Jul 2, 1998·Clinical and Experimental Immunology·C E VisserR H Beelen
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·K A MohammedV B Antony
Mar 11, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·N NasreenV B Antony
Mar 21, 2001·The Journal of Experimental Medicine·E Y LinJ W Pollard
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R L RobsonN Topley
Dec 24, 2002·Seminars in Immunology·Fran Balkwill
Jan 10, 2003·Nucleic Acids Research·Filip PattynJo Vandesompele
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Connie JackamanDelia J Nelson
Jul 13, 2004·Seminars in Cancer Biology·Alberto MantovaniAntonio Sica
Mar 5, 2005·American Journal of Respiratory Cell and Molecular Biology·Pei-Li YaoPan-Chyr Yang
Mar 15, 2005·American Journal of Respiratory and Critical Care Medicine·Joost P J J HegmansBart N Lambrecht
Mar 31, 2005·Advances in Cancer Research·Stephen C Robinson, Lisa M Coussens
Aug 2, 2005·Lancet·Bruce W S RobinsonRichard A Lake
Oct 18, 2005·Biochemical and Biophysical Research Communications·Simon A FoxMichael J Garlepp
Mar 3, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Barrett J Rollins
Mar 3, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Robert M StrieterJohn A Belperio
Mar 7, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Peter SzlosarekFrances R Balkwill
Apr 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thorsten HagemannFrances R Balkwill
Apr 19, 2007·American Journal of Clinical Pathology·Ben DavidsonBjörn Risberg

❮ Previous
Next ❯

Citations

Sep 18, 2013·Biochemical and Biophysical Research Communications·Simon A FoxArun M Dharmarajan
Feb 18, 2015·Frontiers in Psychology·Sabine FrenzelIna Bornkessel-Schlesewsky
Oct 30, 2012·Immunology and Allergy Clinics of North America·Vincent Cottin, Jean-François Cordier
Jul 6, 2012·Journal of Dermatological Science·Myung-Ja KwonTae-Yoon Kim
Mar 25, 2017·Molecular Medicine Reports·Caterina LeddaCarla Loreto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.