Regulated exocytosis in chromaffin cells and cytotoxic T lymphocytes: how similar are they?

Cell Calcium
Ute BechererJ Rettig

Abstract

Chromaffin cells from the adrenal medulla secrete catecholamines into the blood stream as part of the fight-or-flight response. Cytotoxic T lymphocytes from the immune system release cytotoxic substances to kill antigen-presenting cells. While at first glance these two cell types do not seem to have much in common, evidence from human diseases indicates that the molecular mechanisms of exocytosis of the respective granules share many similar features. In this review we highlight the similarities and differences of individual aspects of granule maturation and release in both cell types. In addition, we discuss established and putative molecules involved in distinct steps and suggest technical approaches which might facilitate future studies in chromaffin cells and cytotoxic T lymphocytes.

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Citations

Jan 8, 2016·Biomolecular Concepts·Danielle R J VerboogenGeert van den Bogaart
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Jan 26, 2018·The Journal of Physiology·Xiao ZhouMarkus Hoth
Jun 19, 2020·International Journal of Molecular Sciences·Natalia González-Mancha, Isabel Mérida

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