Regulated hypothermia in the hypothyroid rat induced by administration of propylthiouracil

The American Journal of Physiology
Y Yang, C J Gordon

Abstract

Propylthiouracil (PTU), an antithyroidal drug that reduces serum L-thyroxine (T4) and 3,5,3'-triiodothyronine (T3), is presumed to lower core temperature (T0) by impairing metabolic thermogenesis. However, it is not understood why PTU-treated animals cannot use behavioral and other thermoeffectors to maintain normal Tc. Male rats were administered PTU in drinking water (0.05 mg/ml) while the following parameters were measured: 1) Tc and motor activity (MA) recorded by radiotelemetry for 24 h at ambient temperatures (Ta) of 10-30 degrees C; 2) selected Ta, MA, and Tc in a temperature gradient; and 3) Tc, MA, and grooming behavior during exposure to heat stress (TH = 34.5 degrees C) for 2 h. PTU reduced serum levels of T4, and T3 by 95 and 60%, respectively. Tc decreased after 3 days of PTU treatment; a 0.5 degree C decrease in Tc persisted throughout the PTU treatment. PTU rats exposed to Ta of 10-30 degrees C maintained a consistent hypothermic Tc during the light phase; however, a deficit in the stability of Tc at night was noted during exposure to 10 degrees C. In the temperature gradient, PTU rats selected warmer Ta, but their Tc was maintained at the same hypothermic levels as observed at fixed Ta values of 15-30 degrees C....Continue Reading

Citations

Jun 19, 2002·Journal of Applied Physiology·Alina Maloyan, Michal Horowitz
Nov 27, 2008·American Journal of Physiology. Endocrinology and Metabolism·Eddy RijntjesKatja J Teerds
Sep 5, 2013·Thyroid : Official Journal of the American Thyroid Association·Antonio C BiancoUNKNOWN American Thyroid Association Task Force on Approaches and Strategies to Investigate Thyroid Hormone Economy and Action
Oct 18, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lisa R LeonDavid C Clarke
Nov 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C J GordonB Padnos
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M MaskreyP B Frappell

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