Regulating angiogenesis at the level of PtdIns-4,5-P2.

The EMBO Journal
Eunok Im, Andrius Kazlauskas

Abstract

Angiogenesis is a coordinated sequence of cellular responses that result in the outgrowth of new blood vessels. The angiogenic program is regulated by extracellular factors, whose input is integrated at least in part at the level of signal transduction pathways driven by phosphoinositide 3 kinase (PI3K) and phospholipase Cgamma (PLCgamma). Using an in vitro angiogenesis model, we discovered that PI3K was essential for tube formation, whereas PLCgamma promoted regression. The underlying mechanism by which PLCgamma antagonized tube formation appeared to be by competing with PI3K for their common substrate, phosphatidylinositol-4,5-bisphosphate. These studies are the first to identify signaling enzymes involved with vessel regression, and reveal that the angiogenic program can be coordinated by the availability of a membrane lipid.

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Citations

Feb 28, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Andreas StahlHansjürgen T Agostini
Nov 29, 2008·Cardiovascular Research·Fulvio MorelloEmilio Hirsch
Oct 6, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yoon Jeong ChoiSang Hoon Rhee
Apr 1, 2014·Microvascular Research·Rūta MotiejūnaitėAndrius Kazlauskas
Mar 9, 2010·Gastroenterology·Eunok ImCharalabos Pothoulakis
Feb 14, 2012·The EMBO Journal·Guo-Xiang Ruan, Andrius Kazlauskas
Dec 12, 2012·Journal of Internal Medicine·L Claesson-Welsh, M Welsh
Mar 22, 2007·Expert Opinion on Therapeutic Targets·Eunok Im, Andrius Kazlauskas
Oct 24, 2007·Journal of Vascular Surgery·Seung-Kee MinAlexander W Clowes
Jan 22, 2009·Developmental Cell·Lara C Skwarek, Gabrielle L Boulianne
Aug 11, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Ryoji NagahamaKensuke Egashira
Aug 9, 2007·The Journal of Biological Chemistry·Eunok Im, Andrius Kazlauskas
Mar 7, 2020·Combinatorial Chemistry & High Throughput Screening·Chunli PiaoXiaolin Tong
Jan 8, 2015·The Journal of Biological Chemistry·Sarah Melissa P Jacobo, Andrius Kazlauskas
Mar 7, 2020·Nature Communications·Amber N StratmanBrant M Weinstein
Sep 12, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Annika KoponenVesa M Olkkonen
Nov 24, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Haote HanHetian Lei
Sep 21, 2021·Investigative Ophthalmology & Visual Science·Yueru LiAndrius Kazlauskas
Jan 1, 2022·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Angélica Araceli Ramírez-GuerreroNelly Margarita Macías-Gómez

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