Regulating effect of Chinese herbal medicine on the peritoneal lymphatic stomata in enhancing ascites absorption of experimental hepatofibrotic mice

World Journal of Gastroenterology : WJG
Jicheng LiJian Xu

Abstract

To observe the regulatory effect of Chinese herbal medicine on peritoneal lymphatic stomata and its significance in treating ascites in liver fibrosis model mice. Two Chinese herbal composite prescriptions were used separately to treat the carbon tetrachloride-induced mouse model of liver fibrosis. The histo-pathologic changes of the liver sections (HE and VG stainings) were observed. The peritoneal lymphatic stomata was detected by scanning electron microscopy and computer image processing. The changes of urinary volume and sodium ion concentration were measured. In the model group, lots of fibrous tissue formed in liver and extended into the hepatic lobules to separate them incompletely. In the treated and prevention groups, the histo-pathologic changes of liver was rather milder, only showed much less fibrous tissue proliferation in the hepatic lobules. The peritoneal lymphatic stomata enlarged with increased density in the experimental groups (diameter: PA, 3.07 +/- 0.69 microm; PB, 2.82 +/- 0.37 microm; TA, 3.25 +/- 0.82 microm and TB, 2.82 +/- 0.56 microm; density: PA, 7.11 +/- 1.90 stomata.1000 microm(-2); PB, 8.76 +/- 1.45 stomata.1000 microm(-2); TA, 6.55 +/- 1.44 stomata.1000 microm(-2)and TB, 8.76+/-1.79 stomata.1000...Continue Reading

References

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Citations

Sep 24, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ke QiF William Orr
Feb 27, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Zi-Bin WangJi-Cheng Li
Mar 31, 2004·World Journal of Gastroenterology : WJG·Yan-Jun LuoLi Wang
Jun 12, 2003·World Journal of Gastroenterology : WJG·Wang-Xian TangShao-Bai Li
Jan 24, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Yan-Yuan Li, Ji-Cheng Li

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