Regulating resistance: CncC:Maf, antioxidant response elements and the overexpression of detoxification genes in insecticide resistance

Current Opinion in Insect Science
Craig S Wilding

Abstract

Although genetic and genomic tools have greatly furthered our understanding of resistance-associated mutations in molecular target sites of insecticides, the genomic basis of transcriptional regulation of detoxification loci in insect pests and vectors remains relatively unexplored. Recent work using RNAi, reporter assays and comparative genomics are beginning to reveal the molecular architecture of this response, identifying critical transcription factors and their binding sites. Central to this is the insect ortholog of the mammalian transcription factor Nrf2, Cap 'n' Collar isoform-C (CncC) which as a heterodimer with Maf-S regulates the transcription of phase I, II and III detoxification loci in a range of insects, with CncC knockdown or upregulation directly affecting phenotypic resistance. CncC:Maf binds to specific antioxidant response element sequences upstream of detoxification genes to initiate transcription. Recent work is now identifying these binding sites for resistance-associated loci and, coupled with genome sequence data and reporter assays, enabling identification of polymorphisms in the CncC:Maf binding site which regulate the insecticide resistance phenotype.

Citations

Apr 14, 2020·Archives of Insect Biochemistry and Physiology·Subba Reddy Palli
May 9, 2019·Proceedings of the National Academy of Sciences of the United States of America·Llewellyn GreenCharles Robin
Aug 8, 2019·Scientific Reports·Walter Fabricio Silva MartinsMartin James Donnelly
Apr 25, 2020·Proceedings of the National Academy of Sciences of the United States of America·Xin YangYoujun Zhang
Nov 25, 2018·International Journal of Molecular Sciences·Zhaojiang GuoYoujun Zhang
Jan 3, 2021·Current Opinion in Insect Science·Kai LuRensen Zeng
Dec 30, 2020·Current Opinion in Insect Science·Marilou VandenholeThomas Van Leeuwen
Jan 12, 2021·Toxicology Reports·Yiwen WangBernard Moussian
Apr 12, 2021·Pesticide Biochemistry and Physiology·Dries AmezianGaëlle Le Goff
May 7, 2021·Science Advances·Xin YangYoujun Zhang
Jul 3, 2021·International Journal of Molecular Sciences·Jianying QinZhaojiang Guo
Oct 1, 2021·Annual Review of Entomology·Ralf NauenJohn Vontas
Jan 29, 2022·Archives of Insect Biochemistry and Physiology·Lujuan GaoYiwen Wang

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