Jul 1, 2019

Regulating the development of pulmonary Group 2 innate lymphoid cells

Biological Chemistry
Sofia Helfrich, Claudia U Duerr


Group 2 innate lymphoid cells (ILC2s) are members of the family of innate lymphoid cells and are innately committed to type 2 immune responses. In the lungs, ILC2s are the predominant population of innate lymphoid cells (ILCs) and their development is orchestrated by several different transcription factors ensuring lineage commitment by intrinsic regulation. ILC2s are present in the lungs from the foetal period onwards and are thus exposed to extrinsic regulation due to the airways' continuous morphological changes upon birth. In this review, we will briefly summarise the dependence of ILC2s on transcription factors and discuss recently described characteristics and function of early life ILC2s in the lungs.

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Mentioned in this Paper

Regulation of Biological Process
Transcription, Genetic
Regulation of Intrinsic Apoptosis
Type 2 Immune Response
Lung Neoplasms
Airway Structure
Lymphoid Cells
Lymphoid Cells

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