Regulation and function of odd-paired in Tribolium segmentation

Development Genes and Evolution
Chong Pyo ChoeSusan J Brown

Abstract

The pair-rule gene odd-paired (opa) is required for the patterning of alternate segment boundaries in the early Drosophila embryo. Mutant phenotypes of opa display a typical pair-rule phenotype in which most of each odd-numbered denticle belt is eliminated. However, among the nine Drosophila pair-rule genes, opa is the only gene that is not expressed in stripes with double segmental periodicity; its transcript and protein are expressed in a broad domain within segmenting embryos. While expression patterns of orthologs of opa have been analyzed in several arthropod species, their regulation and function in segmentation were largely unknown. Here, we analyzed the expression patterns, regulation, and function of the Tribolium ortholog of opa (Tc-opa). Tc-opa is expressed in segmental stripes in the early stages of segmentation and then is expressed in a broad domain at the growth zone of elongating germbands where new segments form. This broad expression of Tc-opa is processed into segmental stripes once the trunk has become segmented. Tc-opa expression is regulated positively and negatively by even-skipped and odd-skipped, respectively. However, knock-down of Tc-opa does not affect embryonic segmentation. Our findings suggest tha...Continue Reading

References

Jan 11, 2020·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Carrie A WhittleCassandra G Extavour
Jan 29, 2020·G3 : Genes - Genomes - Genetics·Carrie A WhittleCassandra G Extavour

Citations

Jan 24, 1992·Cell·D St Johnston, C Nüsslein-Volhard
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·Susan J BrownR E Denell
Jan 1, 1994·Developmental Genetics·Susan J BrownR E Denell
Jul 10, 1996·Developmental Biology·Martin KlinglerJ Peter Gergen
Mar 7, 1991·Nature·J J StuartR E Denell
Feb 13, 2002·Current Biology : CB·Gregor BucherMartin Klingler
Apr 6, 2002·Bioinformatics·Heiko A SchmidtArndt von Haeseler
Apr 28, 2004·Developmental Biology·James B Jaynes, Miki Fujioka
Jul 23, 2004·Current Biology : CB·Ariel D ChipmanMichael Akam
Dec 13, 2005·Evolution & Development·Wim G M DamenNikola-Michael Prpic
Apr 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Chong Pyo ChoeSusan J Brown
Mar 1, 2011·EvoDevo·Ralf JanssenWim G M Damen
Mar 10, 2012·Science·Andres F SarrazinMichalis Averof

Related Concepts

Embryo
Biologic Segmentation
Patterns
Gene Knockdown Techniques
Genes
Regulation of Biological Process
Entire Embryo
Widening
odd
Engrailed protein, Tribolium

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