Regulation and function of triacylglycerol lipases in cellular metabolism

The Biochemical Journal
Matthew J Watt, Gregory R Steinberg

Abstract

The ability to store energy in the form of energy-dense TAG (triacylglycerol) and to mobilize these stores rapidly during times of low carbohydrate availability (fasting or famine) or during heightened metabolic demand (exercise or cold-stress) is a highly conserved process essential for survival. Today, in the presence of nutrient excess and sedentary lifestyles, the regulation of this pathway is viewed as an important therapeutic target for disease prevention, as elevated circulating fatty acids in obesity contribute to many aspects of the metabolic syndrome including hepatic steatosis, atherosclerosis and insulin resistance. In the present review, we discuss the metabolic regulation and function of TAG lipases with a focus on HSL (hormone-sensitive lipase), ATGL (adipose triacylglycerol lipase) and newly identified members of the lipolytic proteome.

References

Sep 25, 1992·Proceedings of the National Academy of Sciences of the United States of America·J J EganC Londos
Mar 1, 1991·Molecular & General Genetics : MGG·M W GanalS D Tanksley
Jul 20, 1990·European Journal of Biochemistry·A J Garton, S J Yeaman
Oct 14, 1987·Biochemical and Biophysical Research Communications·C HolmG Fredrikson
Sep 1, 1995·The Journal of Clinical Investigation·G Boden, X Chen
Oct 15, 1996·The Biochemical Journal·T OsterlundC Holm
May 8, 1998·Biochemical and Biophysical Research Communications·T RaclotD Langin
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·W J ShenF B Kraemer
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·J OsugaN Yamada
Aug 19, 2000·The Journal of Biological Chemistry·D L BrasaemleC Londos
Apr 12, 2001·European Journal of Clinical Investigation·J PihlajamäkiM Laakso
Apr 24, 2001·Obesity Research·S P WangG A Mitchell
May 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·J T TanseyC Londos
Oct 3, 2001·The Journal of Biological Chemistry·A S GreenbergF B Kraemer
Nov 22, 2001·The Journal of Biological Chemistry·Guenter HaemmerleRudolf Zechner
Jan 29, 2002·Diabetes·Fatima SmihDominique Langin
Sep 18, 2002·Journal of Applied Physiology·Matthew J WattLawrence L Spriet
Oct 5, 2002·Journal of Lipid Research·Fredric B Kraemer, Wen-Jun Shen
Dec 17, 2002·The Journal of Biological Chemistry·Jacques GroberDominique Langin

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Citations

Oct 11, 2011·Journal of Physiology and Biochemistry·Peter Andrew C McPherson, Jane McEneny
Feb 28, 2009·Acta Physiologica·B D HegartyE W Kraegen
May 19, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Gregory R Steinberg
May 19, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Matthew J Watt
Jun 21, 2013·Journal of Molecular Endocrinology·Heather E BerganMark A Sheridan
Jan 21, 2014·Biochimica Et Biophysica Acta·Sarah A ScottH Alex Brown
May 20, 2014·Pathology, Research and Practice·Takaya Nakanishi, Seiya Kato
Jan 25, 2012·The Journal of Physiology·Jacob Jeppesen, Bente Kiens
Aug 13, 2009·Archives of Physiology and Biochemistry·Phillip J BilanAmira Klip
Jan 16, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zheng LiHao Xu
Oct 4, 2011·Biochimica Et Biophysica Acta·Ariel D Quiroga, Richard Lehner
Mar 9, 2010·Journal of Insect Physiology·Dick J Van der Horst, Kees W Rodenburg
May 30, 2009·Journal of Proteomics·Matthias Schittmayer, Ruth Birner-Gruenberger
Apr 1, 2015·Metabolism: Clinical and Experimental·Jinhan HeGuoheng Xu
Jul 24, 2012·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Theodoros EleftheriadisIoannis Stefanidis
Jul 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kristina M MuellerRichard Moriggl
May 11, 2015·General and Comparative Endocrinology·Heather E BerganMark A Sheridan
Dec 25, 2010·Cell·Edward L HuttlinSteven P Gygi
Feb 15, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Rita D'AscenzoVirgilio P Carnielli
May 2, 2016·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Jian SunLi-Qiao Chen

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