Regulation and functional role of eEF1A2 in pancreatic carcinoma

Biochemical and Biophysical Research Communications
Haixia CaoYongping Zhang

Abstract

Pancreatic cancer typically has an unfavourable prognosis due to late diagnosis and a lack of therapeutic options. Thus, it is important to better understand its pathological mechanism and to develop more effective treatments for the disease. Human chromosome 20q13 has long been suspected to harbour oncogenes involved in pancreatic cancer and other tumours. In this study, we found that eEF1A2, a gene located in 20q13, was significantly upregulated in pancreatic cancer. Little or no expression of eEF1A2 was detected in normal human pancreatic and chronic pancreatitis tissues, whereas increased eEF1A2 expression occurred in 83% of the pancreatic cancers we studied. Furthermore, using in vitro and in vivo model systems, we found that overexpression of eEF1A2 promoted cell growth, survival, and invasion in pancreatic cancer. Our data thus suggest that eEF1A2 might play an important role in pancreatic carcinogenesis, possibly by acting as a tumour oncogene.

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Citations

May 24, 2014·Biochemical and Biophysical Research Communications·Yue SunGuoping Ren
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiao-Shuai YuanJian Hu
Feb 2, 2012·Expert Review of Proteomics·Boris NegrutskiiAnna El'skaya
Nov 11, 2019·Journal of Clinical Medicine·Eun Kyo JoungJi Hyung Hong
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Jul 3, 2021·International Journal of Molecular Sciences·Alberto Mills, Federico Gago

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