Regulation and implications of inflammatory lymphangiogenesis

Trends in Immunology
Honsoul KimGou Young Koh

Abstract

Lymphatic vessels (LVs) are highly dynamic structures that intimately interact with their surrounding microenvironment. They have a profound influence on the immune system and therefore can manipulate inflammatory processes. Inflammation is a major cause of adulthood lymphangiogenesis and LV remodeling. In turn, LVs can reciprocally manipulate inflammatory processes. For instance, LV growth and/or activation regulate antigen presentation and inflammatory cell recruitment to lymph nodes (LNs), and therefore critically affect adaptive immunity. The vascular endothelial growth factor (VEGF)-C-VEGF receptor-3 and VEGF-A-VEGF receptor-2 signaling pathways are particularly important in inflammatory lymphangiogenesis. LVs contribute to the pathophysiology of various inflammatory conditions. Knowledge of lymphatic biology can be applied to manipulate inflammatory disorders and divert immune responses. This review summarizes basic concepts of inflammation-relevant lymphatic biology, and describes recent progress and practical implications.

References

Feb 1, 1996·The Journal of Experimental Medicine·D QianA Weiss
Feb 24, 2004·Journal of the American Society of Nephrology : JASN·Dontscho KerjaschkiIngrid Raab
Dec 31, 2004·Lymphatic Research and Biology·Carla Mouta, Mélanie Heroult
Jan 6, 2005·Journal of the National Cancer Institute·Bronislaw PytowskiMelody A Swartz
Jul 30, 2005·The EMBO Journal·Kentaro KajiyaMichael Detmar
Aug 2, 2005·Nature Reviews. Immunology·Gwendalyn J RandolphMelody A Swartz
Sep 3, 2005·The Journal of Clinical Investigation·Kazuichi MaruyamaJ Wayne Streilein
Dec 16, 2005·Nature·Kari AlitaloTatiana V Petrova
Jan 20, 2007·Physiological Genomics·Nikolaus WickDontscho Kerjaschki
Mar 31, 2007·Lymphatic Research and Biology·Véronique Angeli, Gwendalyn J Randolph
May 31, 2007·The Journal of Experimental Medicine·Maria WirzeniusKari Alitalo
Sep 18, 2007·Nature Biotechnology·Sai T ReddyJeffrey A Hubbell
Apr 2, 2008·Nature Reviews. Immunology·Reinhold FörsterAntal Rot
Sep 19, 2008·Immunity·David AlvarezUlrich H von Andrian
Oct 1, 2008·Nature Reviews. Immunology·Tobias JuntBurkhard Ludewig
Oct 14, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Nicholas W ClavinBabak J Mehrara
Dec 20, 2008·Lymphatic Research and Biology·Leah N Cueni, Michael Detmar
Aug 1, 2009·Plastic and Reconstructive Surgery·Tomer AvrahamBabak J Mehrara
Aug 1, 2009·Nature Reviews. Immunology·Scott N Mueller, Ronald N Germain
Sep 18, 2009·The Journal of Clinical Investigation·Peter BalukDonald M McDonald
Dec 10, 2009·The Journal of Experimental Medicine·Holger Pflicke, Michael Sixt
Dec 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Helia B SchonthalerErwin F Wagner
Jan 23, 2010·The American Journal of Pathology·Li-Chin YaoDonald M McDonald
Feb 6, 2010·Circulation Research·Dimana O MitevaMelody A Swartz
Feb 25, 2010·Cell·Tuomas Tammela, Kari Alitalo

❮ Previous
Next ❯

Citations

Aug 7, 2012·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Taotao LiYulong He
Nov 19, 2013·Inflammopharmacology·Aurélien Fotso FotsoJ P Savineau
Apr 24, 2013·Annals of the American Thoracic Society·Masahiro YamashitaKohei Yamauchi
Mar 5, 2014·The Journal of Clinical Investigation·Honsoul KimGou Young Koh
Mar 5, 2014·The Journal of Clinical Investigation·Wei ZhengKari Alitalo
Feb 8, 2014·Experimental Cell Research·Ellen Berggreen, Helge Wiig
Jan 23, 2014·Angiogenesis·Kar Wai TanVéronique Angeli
Jul 16, 2014·Microvascular Research·Simona Podgrabinska, Mihaela Skobe
Jul 21, 2015·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Alexey DashkevichKarl B Lemström
Aug 9, 2015·Journal of Theoretical Biology·Arianna BianchiJonathan A Sherratt
Apr 30, 2015·Journal of the American Academy of Dermatology·Gilda VarricchiGianni Marone
May 6, 2015·European Journal of Pharmacology·Gianni MaroneFrancescopaolo Granata
Jun 15, 2013·Cytokine·Melissa B Aldrich, Eva M Sevick-Muraca
Apr 13, 2013·The American Journal of Pathology·Philip M KelleyRichard M Tempero
Mar 13, 2014·Blood·Sanja CosoTatiana V Petrova
Sep 13, 2016·Lymphatic Research and Biology·Masahiro YamashitaKohei Yamauchi
Mar 18, 2017·Scientific Reports·Saleh YazdaniJan-Luuk Hillebrands
Jan 15, 2017·Trends in Endocrinology and Metabolism : TEM·Taina VuorioSeppo Ylä-Herttuala
Sep 14, 2013·Journal of Dental Research·E Berggreen, H Wiig
Mar 31, 2015·Inflammatory Bowel Diseases·Felix BeckerJonathan Steven Alexander
Jan 30, 2016·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·Masahiro Yamashita
Oct 31, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shoko HasegawaTakanari Kitazono
Jan 19, 2019·Journal of Periodontal Research·Patrícia Guerra Peixe GonçalvesBruno Cesar de Vasconcelos Gurgel
Sep 7, 2013·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Jeannette Y Wick
Mar 7, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Natalie R NielsenKathleen M Caron
May 27, 2020·Basic Research in Cardiology·Ilona CuijpersEbba Brakenhielm
Sep 12, 2015·American Journal of Physiology. Cell Physiology·Sanjukta ChakrabortyMariappan Muthuchamy
Apr 26, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Abolfazl ZarjouAnupam Agarwal
Jun 6, 2020·Frontiers in Physiology·Raghu P KataruBabak J Mehrara
Aug 14, 2018·The Journal of Clinical Investigation·Hao WuHong Chen
Jul 31, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Saba NayarFrancesca Barone
Jan 15, 2019·Journal of the American Heart Association·Yukiko OeToshihisa Anzai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.