Regulation and improvement of triterpene formation in plant cultured cells of Eriobotrya japonica Lindl

Journal of Bioscience and Bioengineering
Hui-ya HoJin-bin Wu

Abstract

Loquat (Eriobotrya japonica Lindl) is a traditional Chinese medicinal plant that contains triterpenes, which have been shown to exhibit pharmaceutical activities. In this study, we investigated various different culture conditions for cultured cells of loquat to produce triterpenes, including illumination, carbon source, nutrient composition and culture system. When cultured on 2.5mg/l of 6-benzyladenine, 1mg/l of naphthalene acetic acid and 30 g/l of sucrose at 25 ± 2 °C in the dark for 30 days, the nutrient composition significantly regulated the cell growth and triterpene production. Supplied with the Murashige and Skoog medium reached higher level of dry weight (1.27 ± 0.09 g per flask) and total triterpene production (151.54 ± 12.58 mg/g of cultured cells), and the N6 medium produced tormentic acid but inhibited other triterpene products, while the B5 medium produced relatively high corosolic acid. Also found, suspension cultures of loquat cell could achieve high productivity as callus culture.

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Citations

Sep 6, 2014·Natural Product Research·Xu FengJie Luan
May 31, 2016·Journal of Asian Natural Products Research·Xu FengZhi-Yong Chu
May 20, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wen-Ping JiangGuan-Jhong Huang
Mar 5, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chun-Ching ShihHui-Ya Ho
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marta OlechNatalia Nowacka-Jechalke
Aug 21, 2021·Applied Microbiology and Biotechnology·Mariana Zuleima Pérez-González, María Adelina Jiménez-Arellanes

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