PMID: 7537456Apr 1, 1995Paper

Regulation and localization of the insulin-like growth factor system in small bowel during altered nutrient status

The American Journal of Physiology
D E WinesettP K Lund

Abstract

Insulin-like growth factor-I (IGF-I) may regulate small bowel growth. Analyses here in ad libitum-fed, fasted, and refed rats demonstrate that during fasting and refeeding changes in jejunal mass correlate with changes in serum IGF-I and jejunal IGF-I mRNAs. These data indicate that circulating and locally expressed IGF-I contribute to nutrient regulation of jejunal mass. During refeeding, jejunal IGF binding protein 3 (IGFBP-3) mRNA abundance was reduced relative to that of IGF-I, possibly amplifying enterotrophic actions of IGF-I. Localization of IGFBP-3 to subepithelial cells in lamina propria of jejunum indicates that IGFBP-3 derived from lamina propria may modulate IGF-I action on adjacent epithelium. Ileum differed from jejunum in that refeeding did not increase bowel mass or IGF-I mRNA to ad libitum values. Differences in exposure to luminal nutrient may underlie distinct responses of the two segments. Rats fed elemental diet intravenously showed reduced jejunal mass but not reduced jejunal IGF-I mRNA compared with rats fed oral elemental diet. Elemental nutrient given intravenously or orally therefore does not differ in effects on jejunal IGF-I expression. Complex luminal nutrient may, however, regulate jejunal IGF-I ex...Continue Reading

Citations

Aug 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·James G SimmonsP Kay Lund
Oct 23, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·M B GillinghamD M Ney
May 15, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Andrew W KnottBrad W Warner
May 24, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elizabeth M DahlyDenise M Ney
Sep 12, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kristen L WilliamsP Kay Lund
Jun 8, 2006·American Journal of Physiology. Endocrinology and Metabolism·E FernándezC Alvarez
Apr 30, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Prue M Pereira-FantiniJulie E Bines
Aug 14, 2002·World Journal of Gastroenterology : WJG·Yan Gu, Zhao-Han Wu
Sep 8, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·J G SimmonsP K Lund
Jul 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Heather R WilkinsP Kay Lund
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Concepcion Fernandez-EstivarizThomas R Ziegler
Feb 8, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David W NelsonDenise M Ney
Nov 14, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·C A ShoubridgeL C Read

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