PMID: 8959372Jan 1, 1996Paper

Regulation and repair of double-strand DNA breaks

Critical Reviews in Eukaryotic Gene Expression
D T Weaver

Abstract

Double-strand break (DSB) repair in mammalian cells involves in DNA-dependent protein kinase (DNA-PK). DNA-PK is composed of three subunits, a catalytic kinase subunit (DNA-PKcs) mutated in the mouse scid complementation group and the Ku heterodimer. Ku-deficient and DNA-PKcs-deficient cell lines and an animal model have illuminated important features of the DSB repair pathway. Additional factors relevant to several essential functions of DNA replication may point to some overlap between DNA synthesis and DNA repair in eukaryotes. The DNA-PK complex may have broader functions based on its possible involvement in transcriptional regulation and cell cycle checkpoints.

Citations

Apr 16, 2002·The EMBO Journal·Les A Hanakahi, Stephen C West
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May 11, 2000·Molecular and Cellular Biology·C JhappanG Merlino
Mar 10, 2005·Chemical Communications : Chem Comm·Serguei V Kovalenko, Igor V Alabugin
Sep 29, 2005·Biotechnology and Bioengineering·Gargi SethWei-Shou Hu
May 3, 2008·Journal of Materials Science. Materials in Medicine·Xiupeng WangHao Dong
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