Regulation by heat shock protein 22 (HSPB8) of transforming growth factor-α-induced ovary cancer cell migration

Archives of Biochemistry and Biophysics
Mariko SuzukiKen-ichirou Morishige

Abstract

Accumulating evidence suggests that heat shock proteins (HSPs) are implicated in progression of cancer. HSP22 (HSPB8), a small HSP, is recognized to be ubiquitously expressed in various tissues. However, the expression and the role of HSP22 in ovarian cancer remain to be clarified. In the present study, we investigated the involvement of HSP22 in transforming growth factor (TGF)-α-induced migration of ovarian cancer cells. The expression of HSP22 was detected in a serous ovarian cancer cell line, SKOV3.ip1. The migration was reduced by down-regulation of HSP22 expression. The TGF-α-induced migration was reduced by SB203580 (a p38 MAP kinase inhibitor), SP600125 (a SAPK/JNK inhibitor) and Y27632 (a Rho-kinase inhibitor). However, down-regulation of HSP22 had little effect on the TGF-α-induced phosphorylation of p38 MAP kinase, SAPK/JNK and MYPT, a target protein of Rho-kinase. The HSP22 expression was further analyzed in 20 resected specimens of human ovarian serous carcinoma. The expression of HSP22 was detected in all the twenty tissues (8.24-109.22 pg/mg protein), and the cases with highly expression of HSP22 showed a tendency to acquire the progressive ability. Our results strongly suggest that HSP22 acts as a positive regul...Continue Reading

Citations

Jul 12, 2016·Molecular and Cellular Endocrinology·Naohiro YamamotoTakanobu Otsuka
Jul 10, 2019·Scientific Reports·Aleksandra WyciszkiewiczSławomir Michalak
Sep 16, 2020·International Journal of Molecular Sciences·Jixian XiongLi Fu
May 21, 2020·DNA and Cell Biology·Hong SunBing-Li Wu
Oct 30, 2020·Pharmacogenomics and Personalized Medicine·Chenyu YangChengzhan Zhu
Apr 23, 2021·Endocrine Regulations·Oksana S HnatiukOleksandr H Minchenko
May 28, 2021·Experimental and Molecular Pathology·Xia LiYi-Heng Pan

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