Regulation by L-type calcium channels of endocytosis: an overview.

Journal of Molecular Neuroscience : MN
Juliana M RosaLuis Gandia

Abstract

The exocytotic neurotransmitter release process is tightly coupled to the membrane retrieval (endocytosis) process since both are calcium-dependent processes. For instance, at the adrenal chromaffin cells, catecholamine release is regulated by Ca(2+) entry through L, N and PQ subtypes of voltage-dependent calcium channels (VDCC). The contribution of a given VDCC subtype to exocytosis may differ according to the animal species studied, with L channels contributing only about 20 % to the total Ca(2+) entry in bovine chromaffin cells. However, data from electrophysiological experiments with membrane capacitance measurements and fluorescence imaging with FM dyes indicate that Ca(2+) entry through the L-type channels seems to selectively regulate the endocytotic response after the application of a single depolarizing pulse to voltage-clamped bovine chromaffin cells. How do L-type channels control endocytosis remains to be fully clarified. By using specific antibodies against VDCC subtypes and endocytic proteins (i.e. dynamin and clathrin), it has been demonstrated that VDCC subtypes do not co-localise with these proteins. On the other hand, electrophysiological data suggest that the particular mode of sustained Ca(2+) entry through ...Continue Reading

References

Aug 1, 1969·The Journal of Physiology·B Katz, R Miledi
Oct 1, 1980·The Journal of Cell Biology·B Ceccarelli, W P Hurlbut
Sep 1, 1984·Biophysical Journal·E Carbone, H D Lux
Jun 1, 1994·The Journal of Physiology·A AlbillosE Carbone
May 1, 1995·Pflügers Archiv : European journal of physiology·L GandíaA G García
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·C R ArtalejoH C Palfrey
Jun 1, 1994·Pflügers Archiv : European journal of physiology·M G LópezA R Artalejo
Jul 30, 1993·Biochemical and Biophysical Research Communications·L GandíaA G García
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·T A RyanH Reuter
Jun 1, 1996·Current Opinion in Neurobiology·W J BetzC B Smith
Jun 1, 1996·Current Opinion in Neurobiology·A W Henkel, W Almers
Jun 1, 1997·Pflügers Archiv : European journal of physiology·N KitamuraY Nakazato
Apr 4, 1998·Pflügers Archiv : European journal of physiology·B LaraA G García
May 22, 1998·The Journal of Physiology·P G Nucifora, A P Fox
Jun 20, 1998·Pflügers Archiv : European journal of physiology·J M Hernández-GuijoL Gandía
Aug 26, 1998·Pflügers Archiv : European journal of physiology·L GandíaA G García
Jan 29, 1999·The Journal of Cell Biology·M T AlonsoJ Alvarez
Aug 24, 1999·The European Journal of Neuroscience·E A Lukyanetz, E Neher
Jan 29, 2000·Pflügers Archiv : European journal of physiology·G UlateA R Artalejo
Apr 25, 2000·Neuron·E A ErtelW A Catterall
Oct 14, 2000·Annual Review of Cell and Developmental Biology·W A Catterall
Apr 4, 2002·The Journal of General Physiology·Stefan I McDonoughBruce P Bean
Dec 31, 2002·Physiological Reviews·Edward Perez-Reyes
Dec 1, 1964·The Journal of Physiology·W W DOUGLAS, R P RUBIN
Mar 6, 2004·Journal of Bioenergetics and Biomembranes·Clinton J Doering, Gerald W Zamponi

❮ Previous
Next ❯

Citations

Aug 15, 2014·Expert Opinion on Therapeutic Patents·Juan-Alberto Arranz-TagarroJuan-Fernando Padín
Aug 26, 2016·Pflügers Archiv : European journal of physiology·Ricardo De PascualAntonio G García
Sep 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yingshan QiuWanling Liang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.