Regulation by orexin of feeding behaviour and locomotor activity in the goldfish

Journal of Neuroendocrinology
Tomoya NakamachiSeiji Shioda

Abstract

Orexin is a hypothalamic neuropeptide that is implicated in the regulation of feeding behaviour and the sleep-wakefulness cycle in mammals. However, in spite of a growing body of knowledge concerning orexin in mammals, the orexin system and its function have not been well studied in lower vertebrates. In the present study, we first examined the effect of feeding status on the orexin-like immunoreactivity (orexin-LI) and the expression of orexin mRNA in the goldfish brain. The number of cells showing orexin-LI in the hypothalamus of goldfish brain showed a significant increase in fasted fish and a significant decrease in glucose-injected fish. The expression level of orexin mRNA in the brains of fasted fish increased compared to that of fed fish. We also examined the effect of an i.c.v. injection of orexin or an anti-orexin serum on food intake and locomotor activity in the goldfish. Administration of orexin by i.c.v. injection induced a significant increase of food intake and locomotor activity, whereas i.p. injection of glucose or i.c.v. injection of anti-orexin serum decreased food consumption. These results indicate that the orexin functions as an orexigenic factor in the goldfish brain.

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Citations

Jan 18, 2007·Cell and Tissue Research·Kouhei MatsudaAkiyoshi Takahashi
Oct 19, 2007·PLoS Biology·Tohei YokogawaEmmanuel Mignot
Feb 1, 2008·Regulatory Peptides·Eduardo Simão da SilvaJosé Marino-Neto
May 31, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Leah J Hoskins, Hélène Volkoff
Jan 11, 2011·General and Comparative Endocrinology·Kari K Y WongBilly K C Chow
Sep 30, 2010·General and Comparative Endocrinology·Erin E MacDonald, Hélène Volkoff
Aug 6, 2009·Frontiers in Neuroendocrinology·Miguel LópezCarlos Diéguez
Oct 20, 2009·Peptides·Kouhei MatsudaAkiyoshi Takahashi
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Feb 20, 2007·Alcohol·Yuri A BlednovR Adron Harris
Mar 12, 2016·Experimental & Molecular Medicine·Eun RohMin-Seon Kim
May 22, 2009·Annals of the New York Academy of Sciences·Kouhei Matsuda
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Jun 21, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Melissa J S CheeEleftheria Maratos-Flier
May 12, 2006·Peptides·Kouhei MatsudaSeiji Shioda
Oct 7, 2015·Frontiers in Behavioral Neuroscience·Caio MaximinoAnderson Manoel Herculano

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