Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis

The Journal of Clinical Investigation
R S WarrenN Ferrara

Abstract

To investigate the relationship between angiogenesis and hepatic tumorigenesis, we examined the expression of vascular endothelial growth factor (VEGF) in 8 human colon carcinoma cell lines and in 30 human colorectal cancer liver metastases. Abundant message for VEGF was found in all tumors, localized to the malignant cells within each neoplasm. Two receptors for VEGF, KDR and flt1, were also demonstrated in most of the tumors examined. KDR and flt1 mRNA were limited to tumor endothelial cells and were more strongly expressed in the hepatic metastases than in the sinusoidal endothelium of the surrounding liver parenchyma. VEGF monoclonal antibody administration in tumor-bearing athymic mice led to a dose- and time-dependent inhibition of growth of subcutaneous xenografts and to a marked reduction in the number and size of experimental liver metastases. In hepatic metastases of VEGF antibody-treated mice, neither blood vessels nor expression of the mouse KDR homologue flk-1 could be demonstrated. These data indicate that VEGF is a commonly expressed angiogenic factor in human colorectal cancer metastases, that VEGF receptors are up-regulated as a concomitant of hepatic tumorigenesis, and that modulation of VEGF gene expression o...Continue Reading

References

Sep 30, 1992·Biochemical and Biophysical Research Communications·B I TermanP Böhlen
Jun 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R F McGuireF J Roll
Jan 1, 1992·The Journal of Clinical Investigation·L B JakemanN Ferrara
Nov 1, 1991·Journal of Cellular Biochemistry·D T Connolly
Aug 1, 1991·Endocrine Reviews·P A KellyM Edery
Feb 28, 1991·Biochemical and Biophysical Research Communications·J V OlanderJ E DeLarco
Mar 1, 1990·The New England Journal of Medicine·B R Zetter
Mar 15, 1989·International Journal of Cancer. Journal International Du Cancer·L T MaldenA W Burgess
May 15, 1987·International Journal of Cancer. Journal International Du Cancer·R S BresalierY S Kim
Nov 18, 1971·The New England Journal of Medicine·J Folkman
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D S GrantE M Rosen
Jan 4, 1993·Journal of Immunological Methods·D SladowskiM Balls

❮ Previous
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Citations

Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Tatsuyoshi FunasakaHisamitsu Nagase
Nov 15, 2002·International Journal of Cancer. Journal International Du Cancer·Michihisa MoriguchiKeizo Kagawa
Sep 30, 2004·International Journal of Cancer. Journal International Du Cancer·Yves DenizotMuriel Mathonnet
Jun 1, 1996·Cancer Metastasis Reviews·B I Terman, M Dougher-Vermazen
Jun 1, 1996·Cancer Metastasis Reviews·K P Claffey, G S Robinson
Jun 1, 1996·Cancer Metastasis Reviews·P A D'Amore, D T Shima
Jun 1, 1996·Cancer Metastasis Reviews·J Rak, R S Kerbel
Jun 1, 1996·Cancer Metastasis Reviews·V UmanskyV Schirrmacher
Jan 1, 1995·Breast Cancer Research and Treatment·N Ferrara
Dec 1, 1995·Cancer Metastasis Reviews·J RakR S Kerbel
Jul 26, 2000·Diseases of the Colon and Rectum·P GervazS Wexner
Jan 1, 1997·Endocrine Pathology·Martin JugenburgBernd W. Scheithauer
May 12, 2000·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·S ZhengJ Tang
Apr 29, 1998·Pathology Oncology Research : POR·S Paku
Mar 5, 2004·International Journal of Colorectal Disease·Markus GubaChristiane Bruns
Apr 27, 2007·Langenbeck's Archives of Surgery·M E EichhornC J Bruns
Sep 4, 2008·Cell and Tissue Research·Yongping Crawford, Napoleone Ferrara
Sep 11, 2007·Cancer Metastasis Reviews·Tatsuyoshi Funasaka, Avraham Raz
Oct 21, 2009·Clinical & Experimental Metastasis·M Cecilia SubausteElena I Deryugina
Jan 9, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Christopher ChristophiTheodora Fifis
Aug 28, 2003·Current Treatment Options in Oncology·Sharlene GillRichard M Goldberg
Apr 26, 2005·Current Oncology Reports·Naureen Starling, David Cunningham
Oct 7, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G V Koukourakis, A Sotiropoulou-Lontou
Dec 1, 1995·Current Opinion in Biotechnology·G Martiny-Baron, D Marmé
Jun 18, 2005·Biochemical and Biophysical Research Communications·Napoleone FerraraWilliam Novotny
May 14, 2005·Critical Reviews in Oncology/hematology·Andrea Mancuso, Cora N Sternberg
Mar 17, 2004·Seminars in Cancer Biology·Arthur M MercurioJun Chung
Oct 18, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D W SiemannM R Horsman
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N Ferrara

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