Regulation mechanism of Fbxw7-related signaling pathways (Review)

Oncology Reports
Zhenyu ZhouJie Wang

Abstract

F-box and WD repeat domain-containing 7 (Fbxw7), the substrate-recognition component of SCFFbxw7 complex, is thought to be a tumor suppressor involved in cell growth, proliferation, differentiation and survival. Although an increasing number of ubiquitin substrates of Fbxw7 have been identified, the best characterized substrates are cyclin E and c-Myc. Fbxw7/cyclin E and Fbxw7/c-Myc pathways are tightly regulated by multiple regulators. Fbxw7 has been identified as a tumor suppressor in hepatocellular carcinoma. This review focused on the regulation of Fbxw7/cyclin E and Fbxw7/c-Myc pathways and discussed findings to gain a better understanding of the role of Fbxw7 in hepatocellular carcinoma.

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Citations

Jan 10, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Daniel S RobertsChia-Lin Wei
Feb 12, 2019·Oncogene·Irene Vázquez-DomínguezJosé Fernández-Piqueras
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Dec 29, 2019·Biology of Reproduction·Hanbin ZhangZhenguo Chen
Oct 23, 2020·Cancer Research·Mihai I TruicaSarki A Abdulkadir

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