PMID: 6988247Feb 1, 1980Paper

Regulation of 86Rb+ outflow from pancreatic islets. I. Reciprocal changes in the response to glucose, tetraethylammonium and quinine

Molecular and Cellular Endocrinology
A Carpinelli, W J Malaisse

Abstract

Glucose (16.7 mM), tetraethylammonium (TEA; 10.0 mM) and quinine (0.1 mM) all decreased 86Rb fractional outflow rate from isolated pancreatic islets. At the concentration here used, the effect of glucose was not augmented by TEA, suggesting that glucose affected the TEA-sensitive modality of Rb extrusion. The effects of TEA and quinine were not additive. In the presence of quinine which was as potent as glucose in decreasing 86Rb efflux, an early inhibition of 86Rb outlow was still observed in response to glucose administration. However, the latter inhibition was followed by a glucose-induced secondary rise in 86Rb fractional outflow rate. It is proposed that quinine unmasks a dual or discontinuous effect of glucose upon 86Rb+ handling by the islet cells.

Citations

Nov 11, 1982·Pflügers Archiv : European journal of physiology·W J MalaisseA Herchuelz
Aug 1, 1981·Pflügers Archiv : European journal of physiology·W J MalaisseA Sener
Aug 26, 1998·European Journal of Pharmacology·K LouchamiW J Malaisse
Aug 14, 1998·General Pharmacology·L LadrièreW J Malaisse
May 1, 1997·Cellular Signalling·H Jijakli, W J Malaisse
May 15, 1985·European Journal of Biochemistry·W J MalaisseA Sener
Jan 1, 1997·Fundamental & Clinical Pharmacology·H JijakliW J Malaisse
Oct 1, 1980·Journal of Endocrinological Investigation·A R Carpinelli, W J Malaisse
Mar 1, 1982·Metabolism: Clinical and Experimental·G SomersW J Malaisse
Apr 1, 1986·Cell Biochemistry and Function·A R CarpinelliW J Malaisse
Sep 1, 1988·Journal of Endocrinological Investigation·B BillaudelW J Malaisse
Nov 1, 1984·British Journal of Pharmacology·E K Matthews, P A Shotton
Aug 1, 1984·Journal of Endocrinological Investigation·P LebrunW J Malaisse
Jan 22, 1998·The American Journal of Physiology·W J MalaisseA Sener
Dec 9, 1998·The American Journal of Physiology·W J MalaisseW S Zawalich
Jul 1, 1983·The American Journal of Physiology·P LebrunA Herchuelz
Mar 1, 1993·The American Journal of Physiology·W J MalaisseI Valverde
Oct 1, 1985·Biochemical Pharmacology·P C MathiasW J Malaisse
Jul 1, 1984·Biochemical Pharmacology·L BestW J Malaisse

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