PMID: 7009716Oct 1, 1980Paper

Regulation of 86Rb+ outflow from pancreatic islets III. Possible significance of ATP

Journal of Endocrinological Investigation
A R Carpinelli, W J Malaisse

Abstract

Antimycin A, oligomycin or anoxia augmented 86Rb fractional outflow rate (FOR) from prelabelled pancreatic islets, whether in the absence or presence of glucose. This effect could be due to activation of a Ca2+-sensitive modality of K+ extrusion, being little affected by tetraethylammonium and almost completely suppressed by quinine. In the presence of the latter drug, antimycin A still provoked a modest increase in 86Rb FOR, the magnitude of which was positively related to the extracellular glucose concentration and which could correspond to a discharge of mitochondrial 86Rb. It is proposed that the decrease in 86Rb FOR evoked by insulinotropic nutrients (e.g. glucose) may depend, to a limited extent, on an increase in ATP generation rate.

References

Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·L OrciR H Unger
Nov 1, 1977·FEBS Letters·A C BoscheroW J Malaisse
Jan 18, 1978·The Journal of Membrane Biology·W J MalaisseG Somers
Mar 20, 1978·Pflügers Archiv : European journal of physiology·W J MalaisseJ C Hutton
Apr 28, 1978·Annals of the New York Academy of Sciences·W J MalaisseE Rojas
Mar 1, 1979·The American Journal of Physiology·B S Kingsley, J M Frazier
Dec 1, 1975·FEBS Letters·J J Diwan, H Tedeschi
Feb 1, 1973·The Biochemical Journal·S J AshcroftP J Randle
Jan 1, 1970·Progress in Biophysics and Molecular Biology·B Hille
Jul 1, 1980·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J C HuttonW J Malaisse

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Citations

Aug 12, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R B CeddiaR Curi
Aug 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rolando B CeddiaGary Sweeney
Oct 1, 1985·Biochemical Pharmacology·P C MathiasW J Malaisse

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