PMID: 7516973Feb 1, 1994Paper

Regulation of A-currents by cell-cell interactions and neurotrophic factors in developing chick parasympathetic neurones

The Journal of Physiology
M M Dourado, S E Dryer

Abstract

1. The developmental regulation of ion channel expression was studied in parasympathetic neurones isolated from the chick ciliary ganglion. Whole-cell patch clamp recordings were made from ciliary ganglion neurones that were removed from the embryo on the ninth embryonic day (E9) and maintained in dissociated cell culture for an additional 4 days. Previous studies have shown that the expression of a transient voltage-activated K+ current (IA) is regulated by unidentified environmental stimuli during these developmental stages. 2. The effect of interactions between neurones and target tissue on the expression of IA was tested by co-culturing ciliary ganglion neurones with chick striated muscle cells. Neurones from the nerve-muscle co-cultures expressed normal amplitudes of IA, but the neurones did not express normal levels of IA when they were plated onto lysed muscle fibres. 3. The effect of interactions between ganglionic neurones and non-neuronal ganglionic cells was tested by culturing ganglia as explants rather than as dissociated cells. Neurones isolated from the explant cultures did not express normal levels of IA. Similarly, when dissociated ganglionic neurones were co-cultured with fibroblasts isolated from embryonic ch...Continue Reading

Citations

Feb 1, 1994·Current Opinion in Neurobiology·N C SpitzerE Olson
Apr 15, 1999·Annual Review of Neuroscience·A K McAllisterD C Lo
Dec 3, 1999·Journal of Neuroscience Research·R HendriksL K Kaczmarek
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·P Subramony, S E Dryer
Oct 1, 1995·Pflügers Archiv : European journal of physiology·W GuoJ Toyama
Aug 1, 1997·Journal of Cardiovascular Electrophysiology·L C FreemanR F Gilmour
Oct 28, 2005·American Journal of Physiology. Cell Physiology·Laura A SchraderJ David Sweatt
Dec 31, 1997·The European Journal of Neuroscience·R KleeU Heinemann
Jan 1, 1995·Canadian Journal of Physiology and Pharmacology·M E KellyP C Jackson
Feb 24, 2009·Canadian Journal of Physiology and Pharmacology·Mónica GallegoOscar Casis
Feb 9, 2000·American Journal of Physiology. Cell Physiology·K M Hershman, E S Levitan
May 22, 2003·Progress in Neurobiology·Rae Nishi

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