Regulation of a serine protease homolog by the JNK pathway during thoracic development of Drosophila melanogaster

FEBS Open Bio
Ajay Srivastava, Qian Dong

Abstract

The importance of the Jun N-terminal Kinase (JNK) pathway during normal development and tumor invasion has been well documented in Drosophila. Here, this pathway plays important roles in epithelial morphogenesis, wound healing, apoptosis, immunity and regulation of lifespan. However, which downstream molecules facilitate these effects is not very well elucidated. In this study, data are presented on a serine protease homolog (SPH), scarface. These data show that scarface is under regulatory control of the JNK pathway and that this pathway is both necessary and sufficient for its expression within the context of thoracic development. Consequently, down-regulation of scarface results in a thoracic-cleft phenotype that phenocopies the JNK pathway defect. A possible role of scarface during thoracic development in Drosophila is discussed.

References

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Citations

Jun 20, 2017·PLoS Genetics·Tatyana KushnirAharon Helman
Jul 15, 2016·G3 : Genes - Genomes - Genetics·Ana AndjelkovićHoward T Jacobs
Sep 19, 2018·Molecular and Cellular Biology·Ana AndjelkovićHoward T Jacobs
Jul 1, 2020·Immunology Letters·Ghada Tafesh-Edwards, Ioannis Eleftherianos

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Methods Mentioned

BETA
protein trap

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