Regulation of a TATA-binding protein-associated factor during cellular differentiation.

The Journal of Biological Chemistry
H M Alzuherri, Robert J White

Abstract

RNA polymerase III transcription is down-regulated when F9 embryonal carcinoma cells differentiate into parietal endoderm. This reflects a decrease in the activity of TFIIIB, a multisubunit complex that is required for all class III gene expression. Two essential components of TFIIIB are the TATA-binding protein (TBP) and an associated polypeptide called BRF that is specific to this complex. The abundance of both TBP and BRF decreases during F9 cell differentiation. Whereas the amount of TBP assembled into TFIIIB is down-regulated, this is not the case for all TBP-containing complexes. BRF levels show a more dramatic decline that appears sufficient to account for the overall change in transcriptional activity. Developmental regulation of a specific class of genes may therefore be achieved through changes in the availability of a TBP-associated factor.

References

Oct 1, 1992·Genes & Development·T Colbert, S Hahn
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R J WhiteP W Rigby
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J L ManleyM L Gefter
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·G A KassavetisM Pisano
Apr 1, 1995·Molecular and Cellular Biology·R J WhiteS P Jackson
Dec 1, 1993·Molecular and Cellular Biology·R E Meyers, P A Sharp
Jul 1, 1993·Genes & Development·N Hernandez
Dec 1, 1995·Molecular and Cellular Biology·R J WhiteS P Jackson
Oct 17, 1998·DNA Sequence : the Journal of DNA Sequencing and Mapping·C G Larminie, R J White

❮ Previous
Next ❯

Citations

May 6, 2008·The Journal of Biological Chemistry·Sandra A S JohnsonDeborah L Johnson
Nov 30, 2000·Molecular and Cellular Biology·J E SutcliffeR J White
May 9, 2002·Molecular and Cellular Biology·Imogen M JohnstonRobert J White
Mar 17, 2010·BMC Molecular Biology·Dimitris AthineosRobert J White
Oct 5, 2010·Cell Cycle·Hélène Dumay-OdelotMartin Teichmann
Mar 17, 2006·The EMBO Journal·Sarah J GoodfellowRobert J White
Feb 6, 1999·The Journal of Biological Chemistry·H M Alzuherri, R J White
Dec 14, 2001·The Journal of Biological Chemistry·Wolfgang MeissnerKlaus H Seifart
Oct 12, 2000·The Journal of Biological Chemistry·P H ScottR J White
Oct 9, 2002·The Journal of Biological Chemistry·Zoë A Felton-Edkins, Robert J White
Jun 22, 1999·Molecular and Cellular Biology·C G LarminieR J White

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.