May 2, 2003

Regulation of acetate metabolism in a strain of Acinetobacter sp., growing on ethanol

Prikladnaia biokhimiia i mikrobiologiia
T P Pirog, Iu V Kuz'minskaia

Abstract

Ethanol metabolism in Acinetobacter sp. is limited by the rate of acetate assimilation in a reaction catalyzed by acetyl-CoA synthetase (EC 6.2.1.1). Effects of ions (sodium, potassium, and magnesium), byproducts of ethanol and acetaldehyde oxidation (NADH and NADPH), and pantothenic acid on this enzyme have been studied (sodium, NADH, and NADPH inhibit acetyl-CoA synthetase; pantothenic acid, potassium, and magnesium act as the enzyme activators). Conditions of culturing were developed, under which ethanol, acetaldehyde, and acetate in Acinetobacter cells were oxidized at the same rates, producing a threefold increase in the activity of acetyl-CoA synthetase in the cell-free extract. The results of studies of acetyl-CoA synthetase regulation in a mutant strain of Acinetobacter sp., which is incapable of forming exopolysaccharides, provide a basis for refining the technology of ethapolan production, involving the use of C2 substrates.

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Mentioned in this Paper

Pantothenic Acid
Ethanol
Ethanol Measurement
Magnesium Measurement
Blood Pantothenic Acid Analysis
Potassium
Ethanol Metabolism
NADH
Oxidation
Dexol

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