PMID: 6106189Jun 1, 1980Paper

Regulation of acetyl-coA carboxylase: properties of coA activation of acetyl-coA carboxylase

Proceedings of the National Academy of Sciences of the United States of America
L A Yeh, K H Kim

Abstract

Acetyl-CoA carboxylase [acetyl-CoA:carbon-dioxide ligase (ADP-forming), EC 6.4.1.2] is activated by physiological concentrations of CoA. The CoA concentration dependency of this activation is sigmoidal; below 60 microM there is little or no activation, but the activation observed between 60 and 120 microM indicates that small changes in the concentration of CoA can cause significant changes in carboxylase activity. CoA activation of acetyl-CoA crboxylase accompanies polymerization of acetyl-CoA carboxylase. However, the binding site for CoA appears to be different from that of citrate. In contrast to citrate activation, which changes only the Vmax of the reaction, CoA activation of carboxylase results in polymeric forms with a lower Km for acetyl-CoA. The Km for acetyl-CoA is 0.4 mM in the control enzyme, whereas that of the CoA-activated enzyme is as low as 4 microM. The Km for ATP was not changed. Derivatives of CoA were not effective in activating the carboxylase, indicating that the CoA effect is specific. Arguments are presented that CoA could be a physiologically significant positive effector of the carboxylase.

References

Oct 1, 1974·Archives of Biochemistry and Biophysics·C A Carlson, K H Kim
Oct 1, 1974·Archives of Biochemistry and Biophysics·C A Carlson, K H Kim
Jul 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·C GregolinM D Lane
Jun 10, 1970·The Journal of Vitaminology·T NakamuraN Oya

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Citations

Sep 1, 1983·Archives of Biochemistry and Biophysics·B A Lent, K H Kim
Mar 1, 1989·Molecular and Biochemical Parasitology·T N DarlingJ J Blum
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M N Abdel-Halim, S I Farah
Sep 13, 2014·Nature Reviews. Drug Discovery·Frank MadeoGuido Kroemer
Feb 25, 2014·Molecular Cell·Guillermo MariñoGuido Kroemer
Mar 30, 1984·Toxicology and Applied Pharmacology·R K BergeM Farstad
May 29, 1981·Biochemical and Biophysical Research Communications·N R Katz, M Ick
Jan 1, 1982·Progress in Lipid Research·J G McCormack
Jun 1, 1985·Journal of Bacteriology·D S Vallari, C O Rock

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