May 1, 1976

Regulation of acetyl-CoA synthetase of Saccharomyces cerevisiae

Canadian Journal of Microbiology
J S Coleman, J K Bhattacharjee

Abstract

Acetyl-coenzyme A synthetase (EC 6.2.1.1) activity of Saccharomyces cerevisiae was determined by a radioactive assay procedure. The activity in vitro was inhibited significantly by NADPH, NADH, or AMP and to a lesser extent by NADP, NAD, or ADP. Glutamic acid and alpha-ketoglutaric acid were not inhibitory. The enzyme level was repressed when the cells were grown in a complex nutrient medium as opposed to the minimal medium. However, a glutamic acid auxotroph glul, when grown in excess glutamic acid, demonstrated a fivefold increase of acetyl-CoA synthetase.

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Mentioned in this Paper

Saccharomyces cerevisiae allergenic extract
Clinical Enzyme Tests (Procedure)
Coenzyme A Ligases
GLUL gene
Glucose, (beta-D)-Isomer
NADH
Acetyl-coenzyme A Synthetase
NADP
alpha-ketoglutaric acid
Phosphaden

About this Paper

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