Regulation of acinar cell function in the pancreas.

Current Opinion in Gastroenterology
John A Williams

Abstract

This review identifies and puts into context the recent articles which have advanced understanding of the functions of pancreatic acinar cells and the mechanisms by which these functions are regulated. Receptors present on acinar cells, particularly those for cholecystokinin and secretin, have been better characterized as to the molecular nature of the ligand-receptor interaction. Other reports have described the potential regulation of acinar cells by GLP-1 and cannabinoids. Intracellular Ca2+ signaling remains at the center of stimulus secretion coupling and its regulation has been further defined. Recent studies have identified specific channels mediating Ca2+ release from intracellular stores and influx across the plasma membrane. Work downstream of intracellular mediators has focused on molecular mechanisms of exocytosis particularly involving small G proteins, SNARE proteins and chaperone molecules. In addition to secretion, recent studies have further defined the regulation of pancreatic growth both in adaptive regulation to diet and hormones in the regeneration that occurs after pancreatic damage. Lineage tracing has been used to show the contribution of different cell types. The importance of specific amino acids as si...Continue Reading

References

Dec 9, 2003·The Journal of Biological Chemistry·Michiko YamasakiAntony Galione
Feb 24, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Diana D H ThomasGuy E Groblewski
Jun 26, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Chenwei LiJohn A Williams
Apr 7, 2006·American Journal of Physiology. Cell Physiology·Yang CaoMadhav Bhatia
Feb 27, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·S WanR A Travagli
May 10, 2007·Journal of Cellular and Molecular Medicine·Ramasamy TamizhselviMadhav Bhatia
Oct 24, 2007·Pflügers Archiv : European journal of physiology·Stephanie L BarrowAlexei V Tepikin
Dec 18, 2007·Cell·David E Clapham
Dec 28, 2007·American Journal of Physiology. Cell Physiology·Raina Devi RamnathMadhav Bhatia
Mar 21, 2008·Molecular Biology of the Cell·Vijay P Singh, Mark A McNiven
May 3, 2008·The New England Journal of Medicine·Pablo CureRodolfo Alejandro
Sep 9, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·S Vincent WuLaurence J Miller
Sep 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Chiara GabbiJan-Ake Gustafsson
Dec 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Akari InadaSusan Bonner-Weir
Dec 17, 2008·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·G LinariM Broccardo
Dec 18, 2008·American Journal of Physiology. Endocrinology and Metabolism·John A WilliamsMaria E Sabbatini
Jan 23, 2009·Molecular Biology of the Cell·Purnima Bhat, Peter Thorn
Jan 27, 2009·Cellular Signalling·Marc J BernaRobert T Jensen
Mar 14, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ning WengGuy E Groblewski
Apr 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Eugenio Sangiorgi, Mario R Capecchi
Apr 24, 2009·Nature·Peter J CalcraftMichael X Zhu
May 12, 2009·Gastroenterology·Stephen J CrozierJohn A Williams
May 19, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Karen WallaceMatthew C Wright
May 20, 2009·Cell·Jan-Philipp Kruse, Wei Gu
May 29, 2009·Pflügers Archiv : European journal of physiology·Antony GalioneMichael X Zhu
Jun 3, 2009·Nature Cell Biology·Michael D Cahalan
Jul 3, 2009·Current Opinion in Gastroenterology·Sohail Husain, Edwin Thrower
Jul 22, 2009·The Journal of Cell Biology·Eugen BrailoiuSandip Patel
Sep 1, 2009·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Daniel H RapoportCharli Kruse
Oct 10, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·David N CriddleJoseph R Reeve
Nov 17, 2009·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Robert RaffanielloSarwish Rafiq
Nov 20, 2009·British Journal of Pharmacology·Erin E Cawston, Laurence J Miller
Nov 27, 2009·American Journal of Physiology. Cell Physiology·Maria E SabbatiniJohn A Williams
Dec 1, 2009·FEBS Letters·Kyu Pil LeeShmuel Muallem
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Meritxell RoviraSteven D Leach
Dec 25, 2009·American Journal of Physiology. Cell Physiology·Diana D H ThomasGuy E Groblewski

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Citations

Jun 10, 2011·Cellular and Molecular Neurobiology·Xiao Feng Fang, Zong Jie Cui
Nov 23, 2013·Journal of Mammary Gland Biology and Neoplasia·Sandrine TruchetMichèle Ollivier-Bousquet
Aug 2, 2013·Journal of Physiology and Biochemistry·Patricia Santofimia-CastañoAntonio González
Mar 20, 2014·PloS One·Jose L ParedesSohail Z Husain
Oct 30, 2012·Journal of Neurogastroenterology and Motility·Full-Young ChangPaulus S Wang
Oct 18, 2014·Advances in Medical Sciences·Joanna SzklarczykRomana Tomaszewska
Sep 19, 2012·Cellular and Molecular Life Sciences : CMLS·Natalie Porat-ShliomRoberto Weigert
Aug 29, 2012·Surgery·Thomas W Frick
Aug 30, 2011·Gastroenterology·Marina Pasca DiMagliano
Jun 28, 2011·Gastroenterology·David A HessStephen F Konieczny
May 31, 2011·Analytical Biochemistry·Alvin M Shih, Ok-Ho Shin
Feb 3, 2015·Experimental Physiology·Katarzyna Nawrot-PorąbkaStefan Lange
Dec 3, 2014·Molecular and Cellular Endocrinology·Katerina KapodistriaParaskevi Kitsiou
Mar 11, 2017·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Mi Na YoonHyung Seo Park
Dec 14, 2011·Digestive Diseases·Joachim Mössner
Sep 8, 2020·Diabetologia·Mark A AtkinsonKlaus H Kaestner
Aug 3, 2014·Molecular and Cellular Biochemistry·Patricia Santofimia-CastañoAntonio Gonzalez
Aug 7, 2017·Digestive Diseases and Sciences·Massimiliano MutignaniLorenzo Dioscoridi
Aug 2, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Matias EstarasAntonio Gonzalez
Nov 15, 2020·Current Gastroenterology Reports·Nikhil R Thiruvengadam, Michael L Kochman
Apr 24, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Hemanth K KandikattuAnil Mishra

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