Dec 1, 1991

Regulation of adenylyl cyclase by noradrenaline and tumour necrosis factor alpha in rat cardiomyocytes

European Heart Journal
C ReithmannK Werdan


The regulation of adenylyl cyclase components and of adenylyl cyclase activity by noradrenaline and tumour necrosis factor alpha (TNF alpha) was studied in rat cardiomyocytes. Long-term treatment of rat cardiomyocytes in the presence of noradrenaline leads, in addition to a down-regulation of beta 1-adrenoceptors, to an increase in the level of inhibitory G protein alpha-subunits and to a heterologous desensitization of adenylyl cyclase stimulation. Similar to the noradrenaline exposure, incubation of the cardiomyocytes in the presence of the cytokine TNF alpha (10 also increases the level of Gi alpha proteins. However, in contrast to the noradrenaline treatment, which apparently induces a selective up-regulation of Gi alpha, the TNF alpha exposure also increases the level or activity of other components of adenylyl cyclase, such as the level of membrane beta 36-subunits of G proteins and, most likely, the level of the alpha-subunits of the stimulatory G protein (Gs alpha) and the activity of adenylyl cyclase catalytic subunit. While noradrenaline treatment desensitizes receptor-dependent and independent adenylyl cyclase activity, treatment of the cells with TNF alpha induces a sensitization of adenylyl cyclase stimulat...Continue Reading

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Mentioned in this Paper

ATP8A2 gene
Tumor Necrosis Factor-alpha
GNAS gene
IL17F gene
Regulation of Biological Process
Receptor Down-Regulation

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