Regulation of adiponectin in adipocytes upon exposure to HIV-1

HIV Medicine
J-L G SankaléG S Hotamisligil

Abstract

Adipose dysregulation, dyslipidemia, and insulin resistance are hallmarks of HIV-related lipodystrophy. The precise mechanisms behind these disturbances are unknown. In HIV-infected patients, we previously demonstrated a strong relationship between lipodystrophy and levels of adiponectin, an adipose peptide implicated in regulation of glucose and lipid metabolisms. In this study we investigated the effect of HIV on adipocytes, to determine whether HIV can directly infect adipocytes and/or alter the regulation and secretion of the adipocyte-derived hormone adiponectin. Human subcutaneous preadipocytes and adipocytes were exposed to HIV-1 under various conditions. Adiponectin was measured in supernatants and cell lysates. Although adipocytes expressed CD4, the major HIV receptor, they could not be infected in vitro. However, exposure to HIV dramatically increased the secretion of adiponectin from human adipocytes, in the absence of infection. This was exacerbated with sustained exposure to HIV in a transwell assay. Further, human peripheral mononuclear cells also produced adiponectin, but this was largely dependent upon T-cell activation. We propose that the stimulation of adiponectin production by HIV can perturb adiponectin reg...Continue Reading

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Citations

May 24, 2013·Reviews in Endocrine & Metabolic Disorders·Ovidiu GalescuSvetlana Ten
Jun 23, 2012·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Mariam Al-FadhliRaj Raghupathy
Jan 14, 2011·Retrovirology·Timo Z Nazari-ShaftiReza Izadpanah
Dec 1, 2010·Hormone Molecular Biology and Clinical Investigation·Silvia PierottiAndrea M Isidori
Jul 9, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Julia B BalmacedaColleen Hadigan

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