PMID: 8969894Nov 1, 1996Paper

Regulation of adrenal steroidogenesis during chronic stress

Endocrine Research
G AguileraC Camacho

Abstract

The mechanism of the altered adrenal responsiveness during chronic stress was studied by analysis of ACTH and Ang II responses and the expression and activity of steroidogenic enzymes in the adrenal cortex of rats subjected to repeated immobilization (2 hr/day for 14 days), or repeated i.p. injection of 1.5 M NaCl. Concomitant with increased pregnenolone production and reduced aldosterone secretion by isolated adrenal glomerulosa cells of chronically stressed rats, P-450scc mRNA were increased and P-450aldo mRNA levels were decreased in adrenal zona glomerulosa. Consistent with elevated plasma corticosterone levels, isolated adrenal fasciculata cells from stressed rats showed higher cAMP, pregnenolone and corticosterone responses to ACTH. Adrenal fasciculata area and levels of P-450scc, but not those of P-450(11s) hydroxylase were significantly increased. The effects of repeated stress on adrenal steroidogenesis were mimicked by repeated ACTH injections. The half life of corticosterone in plasma measured with [3H]corticosterone was increased in stressed rats but not in ACTH injected rats. This study shows that chronic stress leads to a) inhibition of mineralocorticoid secretion due to inhibition of the late biosynthetic pathway...Continue Reading

References

Aug 18, 1988·The New England Journal of Medicine·P W GoldG P Chrousos
Aug 21, 1980·The New England Journal of Medicine·P E Cryer
Jul 1, 1983·The Journal of Clinical Endocrinology and Metabolism·N SternR D Zipser
Sep 1, 1995·The Journal of Clinical Investigation·G AguileraB Sunar-Akbasak
Dec 1, 1994·Frontiers in Neuroendocrinology·G Aguilera
Apr 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·G Aguilera
Oct 1, 1992·Journal of Neuroendocrinology·M F DallmanC S Cascio

❮ Previous
Next ❯

Citations

Feb 23, 2008·Annals of Medicine·Eva E Redei
Feb 25, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Domenico L Di Curzio, Daniel Goldowitz
Jan 15, 1999·Endocrine Research·C L CoulterI M Bird
Jan 14, 2004·Canadian Journal of Physiology and Pharmacology·Deepak RaiGautam Palit
Jan 4, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jun Ho JeonYoung Yang
Sep 4, 2008·Current Hypertension Reports·Theodore L Goodfriend
Jun 30, 2016·Stress : the International Journal on the Biology of Stress·Natal'ya A Orekhova, Makar V Modorov
May 28, 2019·Canadian Journal of Physiology and Pharmacology·Neeshu SarojJosé A Terrón
Nov 12, 2013·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·A A BozzoM T Mugnaini
Apr 27, 2019·Frontiers in Endocrinology·Marcia H RatnerDavid H Farb
Feb 24, 2001·Endocrine Research·D PignatelliG Defaye
May 10, 2020·Molecular Psychiatry·Charlotte SteenblockStefan R Bornstein
Jan 8, 2004·American Journal of Physiology. Endocrinology and Metabolism·Eric D BruderHershel Raff
Jun 15, 2006·American Journal of Physiology. Endocrinology and Metabolism·Yvonne M Ulrich-LaiJames P Herman
Dec 3, 2014·European Journal of Pharmacology·Anjana Bali, Amteshwar Singh Jaggi
Jul 20, 1999·Molecular and Cellular Endocrinology·W E Rainey
May 12, 2004·Molecular and Cellular Endocrinology·Mary H BassettWilliam E Rainey
Aug 3, 2021·Frontiers in Endocrinology·Arthur D ZimmermanChad D Foradori

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.