PMID: 8969953Nov 1, 1996Paper

Regulation of adrenal vascular tone: role of endothelin-1 and nitric oxide

Endocrine Research
J P HinsonS Kapas

Abstract

The adrenal gland is a highly vascular organ, with a highly conserved and well-regulated blood supply. This study was designed to determine the roles of the local vascular regulators, nitric oxide (NO) and endothelin-1 (ET-1), in the regulation of adrenal vascular tone. Using the in situ intact perfused rat adrenal preparation it was found that the ETA receptor antagonist, BQ123, caused a significant increase in perfusion medium flow rate, while the ETB antagonist, RES-701-1, had no effect. Administration of the NO synthesis, inhibitor, L-NAME, or perfusing medium lacking the substrate for NO synthesis, resulted in a significant decrease in perfusion medium flow rate through the adrenal gland. These results suggest that endogenous endothelin causes a tonic vasoconstriction in the rat adrenal gland, mediated by the ETA receptor and that endogenous NO exerts a tonic vasodilatory effect on the rat adrenal.

Citations

Jan 8, 2000·Clinical and Experimental Pharmacology & Physiology·C Hinojosa-Laborde, D L Lange
Feb 12, 1998·The American Journal of Physiology·G MazzocchiG G Nussdorfer

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