Regulation of adrenomedullin expression and release

Microscopy Research and Technique
N MinaminoY Isumi

Abstract

Adrenomedullin (AM) was originally identified in the extracts of human pheochromocytoma tissue, but this peptide is now known to be synthesized and secreted from many kinds of cells in the body, including vascular smooth muscle cells, endothelial cells, fibroblasts, cardiac myocytes, epithelial cells, and cancer cells. In this review, we summarize AM-secreting and AM gene-expressing cells in addition to the regulation of secretion and gene expression of AM. Although the data are still limited to deduce the general features of AM gene expression, synthesis, and secretion, AM is assumed to be classified into the new class of biologically active peptides, which is mainly expressed and secreted from non-endocrine type cells by the stimulation with inflammation-related substances. It is also interesting that serious physiological conditions such as inflammation or hypoxia potently stimulate AM expression and release, suggesting its unique physiological function distinct from other known biologically active peptides.

References

Jan 1, 1992·Annual Review of Neuroscience·B A EipperR E Mains
Nov 15, 1990·Biochemical and Biophysical Research Communications·M Di RosaS Moncada
May 17, 1991·Journal of Immunological Methods·P MiglioriniS B Corradin
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G GillilandH F Bunn
Oct 13, 1995·Biochemical and Biophysical Research Communications·H ShojiH Matsuo
Oct 24, 1995·Biochemical and Biophysical Research Communications·E N ChiniT P Dousa
Nov 15, 1995·Journal of the American College of Cardiology·T NishikimiH Matsuoka
Apr 1, 1995·Histochemistry and Cell Biology·H WashimineT Eto
Jul 30, 1993·Biochemical and Biophysical Research Communications·K KitamuraT Eto
Apr 1, 1995·Endocrinology·T ImaiF Marumo
Jun 30, 1994·Biochemical and Biophysical Research Communications·S SugoH Matsuo
Mar 21, 1994·FEBS Letters·K KitamuraT Eto
Apr 30, 1993·Biochemical and Biophysical Research Communications·K KitamuraT Eto
May 1, 1996·American Heart Journal·K KobayashiT Eto
Apr 1, 1996·American Heart Journal·K KobayashiT Eto
Feb 1, 1996·Journal of Hypertension·H KanoJ Yoshikawa
Sep 20, 1996·The Journal of Biological Chemistry·M J MillerF Cuttitta
Oct 1, 1996·Genome Research·C A HeidP M Williams
Oct 1, 1996·Genome Research·U E GibsonP M Williams
Dec 1, 1996·Genome Génome / Conseil National De Recherches Canada·C S EchtR Zahorchak
Jan 1, 1997·Life Sciences·T IshiharaT Eto

❮ Previous
Next ❯

Citations

Dec 21, 2004·Angiogenesis·Caroline WilsonMargaret C P Rees
May 12, 2005·Clinical Biochemistry·Ayşe BalatYavuz Coşkun
Nov 7, 2002·Brain Research·Charles E DumontWalter Born
Jun 15, 2004·Neuroreport·Chia-Hsing HuangChia-Hsiang Chen
May 23, 2006·Journal of Paediatrics and Child Health·Ayşe BalatSaime Sahinöz
Mar 13, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Béla KisYoichi Ueta
Jul 20, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takanobu YoshimotoYukio Hirata
Nov 13, 2012·Drug Discovery Today. Disease Models·Jt McGuane, Kp Conrad
Sep 6, 2011·Allergologia et immunopathologia·E KucukosmanogluA Balat
Mar 3, 2011·Regulatory Peptides·Kazuhiko HaradaTomoaki Ikeda
Aug 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Masaomi YamaneShaf Keshavjee
Oct 17, 2015·Digestive Diseases and Sciences·Shinya AshizukaKazuo Kitamura
Jan 27, 2005·Pharmacology & Therapeutics·Shabaz A Hamid, Gary F Baxter
Aug 14, 2013·Neuroscience Letters·Yuki SugimotoMasashi Kawamoto
Jun 14, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Won KimSung Kwang Park
Jan 27, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·I KnerrJ Dötsch
Aug 5, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Won KimSung Kwang Park
Mar 25, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Romain HarmanceyFatima Smih
Mar 17, 2017·Journal of Immunology Research·Shotaro TakanoMasashi Takaso
Jun 18, 2019·The Journal of Clinical Investigation·Andras IringStefan Offermanns
Dec 8, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jackeline AgorretaMercedes Garayoa
Jul 2, 2017·The Journal of Clinical Endocrinology and Metabolism·Yuanlin DongChandrasekhar Yallampalli
Aug 19, 2004·American Journal of Physiology. Endocrinology and Metabolism·Nozomi FukaiYukio Hirata
Aug 28, 2021·Biomedicines·Shinya AshizukaKazuo Kitamura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.