Regulation of Adult Neurogenesis by the Fragile X Family of RNA Binding Proteins

Brain Plasticity
Natalie E PatzlaffXinyu Zhao

Abstract

The fragile X mental retardation protein (FMRP) has an important role in neural development. Functional loss of FMRP in humans leads to fragile X syndrome, and it is the most common monogenetic contributor to intellectual disability and autism. FMRP is part of a larger family of RNA-binding proteins known as FXRs, which also includes fragile X related protein 1 (FXR1P) and fragile X related protein 2 (FXR2P). Despite the similarities of the family members, the functions of FXR1P and FXR2P in human diseases remain unclear. Although most studies focus on FMRP's role in mature neurons, all three FXRs regulate adult neurogenesis. Extensive studies have demonstrated important roles of adult neurogenesis in neuroplasticity, learning, and cognition. Impaired adult neurogenesis is implicated in neuropsychiatric disorders, neurodegenerative diseases, and neurodevelopmental disorders. Interventions aimed at regulating adult neurogenesis are thus being evaluated as potential therapeutic strategies. Here, we review and discuss the functions of FXRs in adult neurogenesis and their known similarities and differences. Understanding the overlapping regulatory functions of FXRs in adult neurogenesis can give us insights into the adult brain and...Continue Reading

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Citations

Mar 31, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·C M Díaz-CanejaC Arango
Jun 3, 2021·International Journal of Molecular Sciences·Chisato KinoshitaKoji Aoyama
Jun 3, 2021·Biology·Olivier Dionne, François Corbin

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Methods Mentioned

BETA
two-hybrid
HITS-CLIP
single cell sequencing
imaging techniques

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