PMID: 3549700Apr 1, 1987

Regulation of allantoate transport in wild-type and mutant strains of Saccharomyces cerevisiae

Journal of Bacteriology
V T ChisholmT G Cooper


Accumulation of intracellular allantoin and allantoate is mediated by two distinct active transport systems in Saccharomyces cerevisiae. Allantoin transport (DAL4 gene) is inducible, while allantoate uptake is constitutive (it occurs at full levels in the absence of any allantoate-related compounds from the culture medium). Both systems appear to be sensitive to nitrogen catabolite repression, feedback inhibition, and trans-inhibition. Mutants (dal5) that lack allantoate transport have been isolated. These strains also exhibit a 60% loss of allantoin transport capability. Conversely, dal4 mutants previously described are unable to transport allantoin and exhibit a 50% loss of allantoate transport. We interpret the pleiotropic behavior of the dal4 and dal5 mutations as deriving from a functional interaction between elements of the two transport systems.


Feb 20, 2008·Biochemistry. Biokhimii︠a︡·I S Shkundina, M D Ter-Avanesyan
Dec 1, 1991·Yeast·R G Buckholz, T G Cooper
Sep 1, 1989·Yeast·R K MortimerJ A Kans
Mar 20, 2013·The Journal of Cell Biology·Michal BrekerMaya Schuldiner
Jan 24, 2006·PLoS Genetics·Oliver R HomannSusan L Lindquist

Related Concepts

Allantoic acid, monosodium salt
Genes, Fungal
Saccharomyces cerevisiae

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