Regulation of alternate peripheral pathways of glucose catabolism during aerobic and anaerobic growth of Pseudomonas aeruginosa.

Journal of Bacteriology
J C Hunt, P V Phibbs

Abstract

Glucose may be converted to 6-phosphogluconate by alternate pathways in Pseudomonas aeruginosa. Glucose is phosphorylated to glucose-6-phosphate, which is oxidized to 6-phosphogluconate during anaerobic growth when nitrate is used as respiratory electron acceptor. Mutant cells lacking glucose-6-phosphate dehydrogenase are unable to catabolize glucose under these conditions. The mutant cells utilize glucose as effectively as do wild-type cells in the presence of oxygen; under these conditions, glucose is utilized via direct oxidation to gluconate, which is converted to 6-phosphogluconate. The membrane-associated glucose dehydrogenase activity was not formed during anaerobic growth with glucose. Gluconate, the product of the enzyme, appeared to be the inducer of the gluconate transport system, gluconokinase, and membrane-associated gluconate dehydrogenase. 6-Phosphogluconate is probably the physiological inducer of glucokinase, glucose-6-phosphate dehydrogenase, and the dehydratase and aldolase of the Entner-Doudoroff pathway. Nitrate-linked respiration is required for the anaerobic uptake of glucose and gluconate by independently regulated transport systems in cells grown under denitrifying conditions.

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Citations

May 22, 2008·Archives of Microbiology·Leith Latrach TlemçaniRidha Mosrati
Jul 14, 2020·Critical Reviews in Biotechnology·Dominik Kopp, Anwar Sunna
Mar 15, 1997·FEMS Microbiology Letters·J F MaD J Hassett
Jul 21, 2005·Journal of Bacteriology·Kelli L PalmerMarvin Whiteley
Oct 22, 2010·BMC Genomics·Julien Tremblay, Eric Déziel
Apr 21, 2009·Applied and Environmental Microbiology·Patrice de WerraMonika Maurhofer
Feb 8, 2008·Applied Microbiology and Biotechnology·Mei ChiaWon Jae Choi

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