Regulation of alternative pathway activation and C3a production by adipose cells

Obesity Research
L N Choy, B M Spiegelman

Abstract

Adipose tissue is a major source of adpisin/factor D of the alternative pathway of complement. Adipose tissue also expresses the two other complement components which are involved in the first activation step of the alternative pathway, factor B and C3, and this step is activated in adipose tissue, producing C3a/Acylation Stimulating Protein (C3a/ASP), a stimulator of triglyceride synthesis. Complement activation is a highly regulated process, however, nothing is known about regulation of complement activation in adipose tissue. To gain insight into the nature of adipose complement activation and its regulation, we have now examined the expression of several complement activation regulatory genes, and analyzed the production of C3a/ASP in lean vs. obese, adpisin-deficient mice. We found that undifferentiated preadipocytes expressed the mRNAs encoding the negative regulatory proteins Crry and factor H, but expression of both genes was decreased upon differentiation. The positive regulator properdin, as well as Crry and factor H, were found in adipose tissue. None of these genes was regulated in murine genetic obesity. To investigate the relative levels of complement activation in lean vs. adpisin-deficient obese mice, we develop...Continue Reading

References

Dec 1, 1978·The Journal of Experimental Medicine·P H Lesavre, H J Müller-Eberhard
Jun 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·I M FaustJ Hirsch
Jan 1, 1989·Complement and Inflammation·J D BechererJ D Lambris
Aug 1, 1989·Thrombosis Research·F EspañaJ H Griffin
Oct 1, 1989·Biochemical Society Transactions·M M Jordan
Jan 1, 1989·Advances in Immunology·D HourcadeJ P Atkinson
Jun 1, 1989·Current Opinion in Immunology·R Kath, M Herlyn
Jul 24, 1987·Science·J S FlierB M Spiegelman
Jun 10, 1986·Journal of Immunological Methods·Y NakanoM Tomita
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K S CookB M Spiegelman
Jan 1, 1980·Advances in Immunology·H J Müller-Eberhard, R D Schreiber
Jan 1, 1993·Immunologic Research·K K Maves, J M Weiler
Sep 1, 1993·The Journal of Clinical Investigation·A BaldoK Cianflone
Jun 1, 1993·The Journal of Experimental Medicine·P W MathiesonD K Peters
Feb 1, 1996·The New England Journal of Medicine·R V ConsidineT L Bauer

❮ Previous
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Citations

Oct 18, 2003·Metabolism: Clinical and Experimental·Zhunan Xia, Katherine Cianflone
Jul 11, 2001·Biochemical and Biophysical Research Communications·M Yoda-MurakamiM Tomita
Oct 17, 2012·Molecular Aspects of Medicine·Carey N Lumeng
May 21, 2013·Seminars in Immunology·Julia PhielerTriantafyllos Chavakis
Oct 17, 2009·Diabetes·José María Moreno-NavarreteJosé Manuel Fernández-Real
Aug 8, 2009·Progress in Brain Research·V Ramaglia, F Baas
Apr 28, 2004·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P W PeakeJ A Charlesworth
Aug 24, 1999·European Journal of Clinical Investigation·M MaslowskaK Cianflone
Aug 5, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M TakahashiY Matsuzawa
Dec 15, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·G IonescuY Inada
Aug 23, 2007·American Journal of Physiology. Endocrinology and Metabolism·Wei CuiKatherine Cianflone
Dec 28, 2007·American Journal of Physiology. Endocrinology and Metabolism·Sabina PaglialungaKatherine Cianflone
Jan 25, 2007·American Journal of Physiology. Endocrinology and Metabolism·Jinhui ZhangXiaoli Chen
Jul 23, 1998·Physiological Reviews·F M GregoireH S Sul
Jul 30, 2020·Annals of Internal Medicine·Michaela R AndersonMatthew R Baldwin
Apr 22, 2021·Archives of Gynecology and Obstetrics·Mikyle DavidThajasvarie Naicker
Jan 25, 2003·Biochimica Et Biophysica Acta·Katherine CianfloneLan Ying Chen

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