Regulation of AMPA receptors and synaptic plasticity

Neuroscience
S D SantosC B Duarte

Abstract

Neuronal activity controls the strength of excitatory synapses by mechanisms that include changes in the postsynaptic responses mediated by AMPA receptors. These receptors account for most fast responses at excitatory synapses of the CNS, and their activity is regulated by various signaling pathways which control the electrophysiological properties of AMPA receptors and their interaction with numerous intracellular regulatory proteins. AMPA receptor phosphorylation/dephosphorylation and interaction with other proteins control their recycling and localization to defined postsynaptic sites, thereby regulating the strength of the synapse. This review focuses on recent advances in the understanding of the molecular mechanisms of regulation of AMPA receptors, and the implications in synaptic plasticity.

References

Apr 15, 1992·The Journal of Comparative Neurology·R S Petralia, R J Wenthold
Aug 3, 1990·Science·K KeinänenP H Seeburg
Sep 1, 1995·Journal of Neuroscience Research·V Gallo, J T Russell
Feb 7, 1998·Science·P M LledoR A Nicoll
Jun 11, 1998·Science·C RosenmundC F Stevens
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·D V LissinM von Zastrow
Jul 16, 1999·Neurochemistry International·J J Woodward
Aug 14, 1999·Science·F G Giancotti, E Ruoslahti
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·R C CarrollM von Zastrow
Feb 25, 2000·The International Journal of Biochemistry & Cell Biology·M G Coppolino, S Dedhar
Mar 29, 2000·FEBS Letters·N KlugbauerF Hofmann
Apr 5, 2000·The Journal of Biological Chemistry·K HironakaT Yamamoto
Jun 9, 2000·Annual Review of Neuroscience·S J MartinR G Morris
Jun 14, 2000·Current Opinion in Neurobiology·R MalinowY Hayashi

❮ Previous
Next ❯

Citations

Apr 25, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yue HuXiaoPing Zhang
Nov 19, 2013·Pflügers Archiv : European journal of physiology·Christof GrewerThomas Rauen
Nov 3, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Botros B Kostandy
Apr 24, 2012·Nature Neuroscience·Sophie E L ChamberlainJack R Mellor
Mar 23, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ainhoa Plaza-ZabalaFernando Berrendero
Nov 18, 2011·Proceedings of the National Academy of Sciences of the United States of America·Filip A KonopackiJeremy M Henley
May 17, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sharon A SwangerGary J Bassell
Mar 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jang-Su ParkYuan-Xiang Tao
Apr 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jung-Hwa Tao-ChengThomas S Reese
Dec 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Luís F RibeiroAna Luísa Carvalho
Jan 7, 2014·Pflügers Archiv : European journal of physiology·Guiscard SeebohmNathalie Strutz-Seebohm
Jul 11, 2014·Cognitive Neurodynamics·Francesco Ventriglia
Feb 26, 2011·The International Journal of Neuroscience·Dimitrios MichmizosStavros Baloyannis
May 3, 2014·Molecular and Cellular Neurosciences·Victoria M HoKelsey C Martin
Nov 27, 2015·Brain : a Journal of Neurology·Pishan ChangRobin S B Williams
Jan 28, 2016·Cellular and Molecular Neurobiology·Dorian CaudalBill P Godsil
Oct 23, 2012·Behavioural Brain Research·B Á Nic DhonnchadhaK M Kantak
Sep 13, 2011·Behavioural Brain Research·Hana MaláJesper Mogensen
Mar 23, 2011·Trends in Neurosciences·Jeremy M HenleyOleg O Glebov
Aug 3, 2010·Neuroscience Letters·Ana Lucia Beirão CabralCláudio Antonio Barbosa de Toledo
Nov 26, 2008·Neuroscience·S DavangerO P Ottersen
Aug 10, 2013·Journal of Neurochemistry·David A DavisCaleb E Finch
Aug 14, 2012·The European Journal of Neuroscience·Maria A EsparzaLiliana M Cancela
Sep 4, 2012·The FEBS Journal·Wiljan J A J HendriksJeroen den Hertog
Aug 10, 2015·Molecular and Cellular Neurosciences·Johanna G PasekRoger J Colbran
Dec 20, 2014·Hippocampus·Amanda L Jacob, Richard J Weinberg
May 18, 2016·Neural Plasticity·Marija KamcevaPaul J Lombroso
Aug 6, 2013·Neuroscience·E SoaresF C Pereira

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.