PMID: 9417142Feb 14, 1998Paper

Regulation of an inwardly rectifying ATP-sensitive K+ channel in the basolateral membrane of renal proximal tubule

The Journal of General Physiology
U R MauererA S Segal

Abstract

Functional coupling of Na+,K+-ATPase pump activity to a basolateral membrane (BLM) K+ conductance is crucial for sustaining transport in the proximal tubule. Apical sodium entry stimulates pump activity, lowering cytosolic [ATP], which in turn disinhibits ATP-sensitive K+ (KATP) channels. Opening of these KATP channels mediates hyperpolarization of the BLM that facilitates Na+ reabsorption and K+ recycling required for continued Na+,K+-ATPase pump turnover. Despite its physiological importance, little is known about the regulation of this channel. The present study focuses on the regulation of the BLM KATP channel by second messengers and protein kinases using membrane patches from dissociated, polarized Ambystoma proximal tubule cells. The channel is regulated by protein kinases A and C, but in opposing directions. The channel is activated by forskolin in cell-attached (c/a) patches, and by PKA in inside-out (i/o) membrane patches. However, phosphorylation by PKA is not sufficient to prevent channel rundown. In contrast, the channel is inhibited by phorbol ester in c/a patches, and PKC decreases channel activity (nPo) in i/o patches. The channel is pH sensitive, and lowering cytosolic pH reduces nPo. Increasing intracellular [...Continue Reading

References

Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K TsuchiyaP A Welling
Oct 1, 1992·Physiological Reviews·N A McCarty, R G O'Neil
Nov 1, 1992·Pflügers Archiv : European journal of physiology·B Allard, M Lazdunski
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P R SmithD J Benos
Mar 1, 1991·Pflügers Archiv : European journal of physiology·M Hunter
Jan 1, 1992·Physiological Reviews·F Lang, W Rehwald
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·W H Wang, G Giebisch
Mar 1, 1991·The Journal of Membrane Biology·J Y Lapointe, M Duplain
Jan 1, 1990·Cellular Signalling·S J Ashcroft, F M Ashcroft
Aug 1, 1990·Pflügers Archiv : European journal of physiology·S J ReshkinH Murer
Feb 1, 1990·Pflügers Archiv : European journal of physiology·K Kawahara
Apr 1, 1990·Pflügers Archiv : European journal of physiology·T Ohno-ShosakuM Fujimoto
Jan 1, 1985·Annual Review of Biochemistry·F Eckstein
Oct 1, 1987·Pflügers Archiv : European journal of physiology·H Gögelein, R Greger
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L B MargolisV P Skulachev
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H Sackin
Jul 1, 1988·Pflügers Archiv : European journal of physiology·H Völkl, F Lang
Aug 1, 1988·Pflügers Archiv : European journal of physiology·M Hunter, G Giebisch
Oct 1, 1988·Pflügers Archiv : European journal of physiology·J UblH A Kolb
Jan 1, 1987·The Journal of Membrane Biology·P S Steels, E L Boulpaep
May 1, 1985·Pflügers Archiv : European journal of physiology·G MessnerF Lang
May 1, 1985·Pflügers Archiv : European journal of physiology·G MessnerF Lang
Jan 1, 1984·The Journal of Membrane Biology·Y MatsumuraG Giebisch
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R S BalabanJ M Storey
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Aug 1, 1994·Pflügers Archiv : European journal of physiology·L Robson, M Hunter
Jan 1, 1995·Annual Review of Physiology·H Sackin
Jun 1, 1995·The American Journal of Physiology·A G PratH F Cantiello
Jul 1, 1993·Pflügers Archiv : European journal of physiology·E Honoré, M Lazdunski
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·C M McNicholasG Giebisch
Dec 1, 1993·The American Journal of Physiology·A D Bonev, M T Nelson
Jul 1, 1993·The American Journal of Physiology·A G PratH F Cantiello
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·G Edwards, A H Weston

❮ Previous
Next ❯

Citations

Jan 16, 2007·Pflügers Archiv : European journal of physiology·Mariano L LopardoCarlos Amorena
Jun 26, 2013·The Journal of Physiological Sciences : JPS·Kazuyoshi NakamuraManabu Kubokawa
Feb 15, 2001·European Journal of Pharmacology·C MartínezM J García de Boto
Aug 6, 2000·British Journal of Pharmacology·R EngbersenF G Russel
Dec 15, 2000·Acta Physiologica Scandinavica·G Giebisch, W Wang
Jun 3, 2011·Proceedings of the National Academy of Sciences of the United States of America·Marc PaulaisStephen J Tucker
Feb 24, 2004·Annual Review of Physiology·Xiang Dong TangToshinori Hoshi
Feb 18, 2012·American Journal of Physiology. Renal Physiology·Kirk L Hamilton, Daniel C Devor
Aug 9, 2001·The Japanese Journal of Physiology·Y MoriT Kubota
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·W P DubinskyS G Schultz
Nov 4, 2008·Biochemical and Biophysical Research Communications·Wei ZhangVedat Schwenger
Sep 18, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Dusan CemerikicJovica Milovanovic
Mar 19, 2003·British Journal of Pharmacology·Pedro Gomes, Patrício Soares-da-Silva
Apr 23, 2003·Pflügers Archiv : European journal of physiology·Richard Warth
Apr 10, 2004·Circulation Research·Renee A PulverKaren M Lounsbury
Jul 16, 2008·Physiological Reviews·Dirk Heitzmann, Richard Warth
Mar 7, 2002·American Journal of Physiology. Cell Physiology·Yingjun Li, Dan R Halm
Dec 15, 2015·Physiological Reviews·Monique N Foster, William A Coetzee
Jul 15, 2015·American Journal of Physiology. Cell Physiology·Sona Lakshme BalasubramaniamSonali P Barwe
Oct 9, 1999·The Journal of Biological Chemistry·K KurashimaS Grinstein
Dec 30, 2014·Physiological Reviews·Francisco V SepúlvedaMaría Isabel Niemeyer
Apr 6, 2000·American Journal of Physiology. Renal Physiology·M TanemotoJ Z Xu
Apr 6, 2002·American Journal of Physiology. Renal Physiology·Marc PaulaisJacques Teulon
Aug 15, 2001·American Journal of Physiology. Cell Physiology·J Y JunK M Sanders
Jun 5, 1998·The American Journal of Physiology·G Giebisch
Sep 10, 2002·American Journal of Physiology. Renal Physiology·Kazuyoshi NakamuraManabu Kubokawa
Jun 13, 2002·American Journal of Physiology. Renal Physiology·Craig G HurwitzAlan S Segal
Nov 8, 2013·American Journal of Physiology. Cell Physiology·Alban Girault, Emmanuelle Brochiero
Jun 13, 2002·American Journal of Physiology. Renal Physiology·Pedro Gomes, P Soares-Da-Silva

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.