PMID: 7541940Jun 1, 1995Paper

Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents

The American Journal of Physiology
J M GleadleP Ratcliffe

Abstract

Recent work has indicated that oxygen-sensing mechanism(s) resembling those controlling erythropoietin production operate in many non-erythropoietin-producing cells. To pursue the implication that such a system might control other genes, we studied oxygen-regulated expression of mRNAs for vascular endothelial growth factor, platelet-derived growth factor (PDGF) A and B chains, placental growth factor (PLGF), and transforming growth factor in four different cell lines and compared the characteristics with those of erythropoietin regulation. Oxygen-regulated expression was demonstrated for each gene in at least one cell type. However, the response to hypoxia (1% oxygen) varied markedly, ranging from a 13-fold increase (PDGF-B in Hep G2 cells) to a 2-fold decrease (PLGF in the trophoblastic line BeWo). For each gene/cell combination, both the magnitude and direction of the response to hypoxia were mimicked by exposure to cobaltous ions or two different iron-chelating agents, desferrioxamine and hydroxypyridinones. These similarities with established characteristics of erythropoietin regulation indicate that a similar mechanism of oxygen sensing is operating on a variety of vascular growth factors, and they suggest that chelatable ...Continue Reading

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Citations

Apr 25, 1997·The Journal of Biological Chemistry·C W PughP J Ratcliffe
Jun 5, 2003·Nature Medicine·Christopher W Pugh, Peter J Ratcliffe
Oct 18, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sandeep BatraPunam Malik
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Jan 22, 2011·Journal of Cellular and Molecular Medicine·Aude CarreauClaudine Kieda
Aug 8, 2014·Metallomics : Integrated Biometal Science·Zhen ZhangY James Kang
Apr 23, 2015·Expert Reviews in Molecular Medicine·Justin DragerJake Barralet
Aug 8, 2018·The Journal of Biological Chemistry·Xiaojuan LiuY James Kang
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Feb 21, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tobias LindenRoland H Wenger

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