PMID: 9427502Jan 14, 1998Paper

Regulation of anterior pituitary galanin gene expression by thyroid hormone

Brain Research. Molecular Brain Research
S C HooiL M Kaplan

Abstract

Thyroid hormone is required for basal and estrogen-induced expression of anterior pituitary galanin. Steady-state anterior pituitary galanin mRNA levels decreased 6-fold in hypothyroid rats after 3 weeks of treatment. Similarly, hypothyroidism resulted in a 2.6-fold decrease in estrogen induction of galanin gene expression. The effect of thyroid hormone on anterior pituitary galanin gene expression appears to be exerted, at least in part, at the pituitary itself. Transient expression assays in GH3 cells suggest the involvement of transcriptional mechanisms in the regulation of galanin gene expression by thyroid hormone. A region between -41 and -132 bp upstream of the transcriptional start site confers thyroid hormone responsiveness to the galanin gene. Gel-mobility shift assays show specific binding of 'SPI-like' proteins in GH3 nuclear extracts to this region of the galanin gene. This binding was greatly enhanced by thyroid hormone.

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Citations

Oct 31, 2003·Trends in Neurosciences·Ruud UbinkTomas Hökfelt
Oct 3, 1998·Brain Research. Molecular Brain Research·A Rökaeus, J A Waschek
Aug 21, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Vincenzo Cimini
Feb 3, 1999·Annals of the New York Academy of Sciences·I Merchenthaler
Feb 3, 1999·Annals of the New York Academy of Sciences·E J MufsonD C Deecher
Feb 3, 1999·Annals of the New York Academy of Sciences·M A Miller
Feb 3, 1999·Annals of the New York Academy of Sciences·L CalzàT Hökfelt
Jan 14, 2009·Neurological Research·Gloria A MachiavelliJosé A Burdman
Jul 30, 2015·Expert Opinion on Therapeutic Targets·Krista FreimannÜlo Langel
Nov 23, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Osama M AhmedR G Ahmed
Dec 20, 2000·American Journal of Physiology. Endocrinology and Metabolism·Q L LiT C Friedman
Nov 19, 2020·International Journal of Molecular Sciences·Cecilia Zavala-TecuapetlaHiram Luna-Munguia

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