PMID: 4886042Mar 1, 1969Paper

Regulation of antibody synthesis against Escherichia coli endotoxin. IV. Induction of paralysis in vitro by treating normal lymphoid cells with antigen

The Journal of Experimental Medicine
S Britton

Abstract

Normal mouse lymphoid cells have been shown to become specifically paralyzed after in vitro exposure to high doses of detoxified endotoxin of Escherichia coli 055:B5. The immune status of the treated cells was tested after transfer to secondary irradiated hosts. Paralysis was shown to be initiated by events taking place in vitro, since the amount of antigen retained on the cells after the in vitro exposure was insufficient to induce paralysis in vivo. The induction of paralysis was dependent on the concentration of antigen added to the cells in vitro. Certain variables, such as time of exposure and temperature at exposure, influenced the ease by which the cells could be paralyzed. Cells pretreated with trypsin were not susceptible to induction of paralysis by the above procedure.

References

Jul 12, 1968·Science·J Woodruff, B M Gesner
Sep 1, 1965·The Journal of Experimental Medicine·M LandyA L Jackson
Jan 1, 1957·Annual Review of Medicine·D W TALMAGE
Jan 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·P C FREIG J THORBECKE
Jun 1, 1965·The Journal of Experimental Medicine·G MOLLER, H WIGZELL

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Citations

Sep 1, 1972·Cellular Immunology·E Diener, M Feldmann
Dec 12, 2001·Trends in Biochemical Sciences·J A Witkowski
Sep 27, 1969·Nature·J L AtkinsonP W Ratcliff
Nov 1, 1970·The Journal of Experimental Medicine·W W Bullock, M B Rittenberg
Jun 1, 1974·The Journal of Experimental Medicine·J W Schrader, G J Nossal
Jan 1, 1972·Transplantation Reviews·P Bretscher
Jan 1, 1972·Transplantation Reviews·W O WeigleG S Habicht
Jan 1, 1972·Transplantation Reviews·E Möller, O Sjöberg
Jan 1, 1972·Transplantation Reviews·E Diener, M Feldmann
Jan 1, 1975·Transplantation Reviews·G J Nossal, J W Schrader
Sep 1, 1971·Journal of Medical Genetics·J Bradley, C J Elson
Nov 17, 2004·Shock·Carol L WellsStanley L Erlandsen
Sep 15, 1971·Nature: New Biology·J L Allen, H Friedman
Aug 1, 1972·European Journal of Immunology·J AnderssonG Möller
Mar 1, 1976·The Journal of Surgical Research·R E Falk, A B MacGregor

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