Regulation of apoptosis and autophagy in mouse and human skeletal muscle with aging and lifelong exercise training

Experimental Gerontology
Maja Munk DethlefsenHenriette Pilegaard

Abstract

Exercise training has been reported to prevent the age-induced decline in muscle mass and fragmentation of mitochondria, as well as to affect autophagy and mitophagy. The interaction between these pathways during aging as well as the similarity between such changes in human and mouse skeletal muscle is however not fully understood. Therefore the aim of the present study was to test the hypothesis that cellular degradation pathways, including apoptosis, autophagy and mitophagy are coordinately regulated in mouse and human skeletal muscle during aging and lifelong exercise training through a PGC-1α-p53 axis. Muscle samples were obtained from young untrained, aged untrained and aged lifelong exercise trained men, and from whole-body PGC-1α knockout mice and their littermate controls that were either lifelong exercise trained or sedentary young and aged. Lifelong exercise training prevented the aging-induced reduction in PGC-1α, p53 and p21 mRNA as well as the increase in LC3II and BNIP3 protein in mouse skeletal muscle, while aging decreased the BAX/Bcl-2 ratio, LC3I and BAX protein in mouse skeletal muscle without effects of lifelong exercise training. In humans, aging was associated with reduced PGC-1α mRNA as well as decreased ...Continue Reading

Citations

Feb 2, 2019·Pflügers Archiv : European journal of physiology·Tomohiro TanakaMotohiro Nishida
Mar 14, 2019·CNS Neuroscience & Therapeutics·Jun HuangFang Lin
Sep 20, 2019·Genes·Carlo Maria Di LiegroItalia Di Liegro
Jun 10, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jens Frey Halling, Henriette Pilegaard
Oct 2, 2019·Frontiers in Cell and Developmental Biology·Kathrin Schmeisser, J Alex Parker
Dec 26, 2018·Expert Opinion on Therapeutic Targets·Anna PiccaEmanuele Marzetti
Feb 9, 2019·Bone·Vanessa D Sherk, Clifford J Rosen
May 10, 2021·Acta Neuropathologica Communications·Nicole SchwabLili-Naz Hazrati
Aug 17, 2021·Medicine and Science in Sports and Exercise·Hao-En GaoLei Sun

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.