Regulation of apoptosis and cell cycle activity in rheumatoid arthritis

Current Molecular Medicine
H PerlmanM V Volin

Abstract

The regulation of proliferation and cell death is vital for homeostasis, but the mechanisms that coordinately balances these two events in rheumatoid arthritis (RA) remains largely unknown. In RA, the synovial lining increases through enhanced proliferation, migration, and/or decreased cell death. The aberrant decrease in apoptosis or increased cell cycle activity of fibroblast-like or macrophage-like synoviocytes is responsible for the synovial hyperplasia and contributes to the destruction of cartilage and bone. Recently, numerous molecules that modulate apoptosis and cell cycle have been implicated to play a role in RA. This review will describe the current understanding of the molecular mechanisms that govern apoptosis and cell cycle and their relationship to RA pathogenesis.

Citations

Mar 7, 2006·Clinical Rheumatology·Chikako Takahashi TohyamaHajime Ishikawa
May 12, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Adam MorMichael H Pillinger
Apr 21, 2005·Seminars in Cell & Developmental Biology·Julie P I Welburn, Jane A Endicott
Jun 16, 2005·Journal of Pediatric Hematology/oncology·Micha I BankBodil Laub Petersen
Sep 17, 2003·Genes & Development·Tetsuya AmanoToshihiro Nakajima
May 19, 2007·Arthritis Research & Therapy·John C ScatizziHarris Perlman
Sep 24, 2009·Current Rheumatology Reports·Melissa MaversHarris Perlman
May 11, 2010·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Feng-Xia WuGuo-Hua Yuan
Jun 21, 2015·Journal of the American Chemical Society·Alexandre BarrozoShina C L Kamerlin
Jul 30, 2016·Journal of the American Chemical Society·Fernanda DuarteShina C L Kamerlin
Dec 28, 2016·Journal of the American Chemical Society·David Blaha-NelsonShina Caroline Lynn Kamerlin
Jan 30, 2004·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Deding TaoJianping Gong
Feb 12, 2004·Arthritis and Rheumatism·Huang-Ge ZhangJohn D Mountz
Jun 10, 2004·The Journal of Veterinary Medical Science·Junichi SanoAtsuhiko Hasegawa
May 5, 2005·The Journal of Pharmacology and Experimental Therapeutics·Natsuko KusunokiShinichi Kawai
Apr 12, 2007·Archives of Pathology & Laboratory Medicine·Ari KobayashiYasunori Okada

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.