Regulation of apoptosis/necrosis execution in cadmium-treated human promonocytic cells under different forms of oxidative stress

Apoptosis : an International Journal on Programmed Cell Death
P SanchoP Aller

Abstract

Pulse-treatment of U-937 human promonocytic cells with cadmium chloride followed by recovery caused caspase-9/caspase-3-dependent, caspase-8-independent apoptosis. However, pre-incubation with the glutathione (GSH)-suppressing agent DL-buthionine-(S,R)-sulfoximine (cadmium/BSO), or co-treatment with H2O2 (cadmium/H2O2), switched the mode of death to caspase-independent necrosis. The switch from apoptosis to necrosis did not involve gross alterations in Apaf-1 and pro-caspase-9 expression, nor inhibition of cytochrome c release from mitochondria. However, cadmium/H2O2-induced necrosis involved ATP depletion and was prevented by 3-aminobenzamide, while cadmium/BSO-induced necrosis was ATP independent. Pre-incubation with BSO increased the intracellular cadmium accumulation, while co-treatment with H2O2 did not. Both treatments caused intracellular peroxide over-accumulation and disruption of mitochondrial transmembrane potential (delta psi m). However, while post-treatment with N-acetyl-L-cysteine or butylated hydroxyanisole reduced the cadmium/BSO-mediated necrosis and delta psi m disruption, it did not reduce the effects of cadmium/H2O2. Bcl-2 over-expression, which reduced peroxide accumulation without affecting the intracellu...Continue Reading

References

May 15, 1976·International Journal of Cancer. Journal International Du Cancer·C Sundström, K Nilsson
Oct 1, 1985·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·C D KlaassenJ J Hjelle
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Jul 29, 1998·Chemico-biological Interactions·H H Bailey
Jul 3, 1999·The Journal of Biological Chemistry·Y J Lee, E Shacter
Dec 20, 2000·Experimental Cell Research·B SingleP Nicotera
Mar 30, 2001·The Journal of Biological Chemistry·M D MiramarS A Susin
Aug 30, 2001·Cell Death and Differentiation·G DeneckerP Vandenabeele
Dec 26, 2001·Pharmacology & Therapeutics·K C ZimmermannD R Green
Dec 26, 2001·Toxicology·Masuo KondohMasao Sato
Mar 27, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·L F BarrosJ Castro
Sep 6, 2002·Biochemical Pharmacology·Dale A Dickinson, Henry Jay Forman
Sep 28, 2002·Nature·Jeffrey A KleinSusan L Ackerman
Mar 19, 2003·British Journal of Pharmacology·E LópezM P González
Apr 22, 2003·Journal of Cellular Biochemistry·Chwen-Ming ShihChien-Tsu Chen
May 7, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Seema SomjiDonald A Sens
Aug 19, 2004·Journal of Cell Science·Céline CandéGuido Kroemer
Nov 5, 2004·The EMBO Journal·Nicola VahsenGuido Kroemer

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Citations

Aug 29, 2013·Archives of Toxicology·Frank Thévenod, Wing-Kee Lee
May 9, 2008·Apoptosis : an International Journal on Programmed Cell Death·Amrita M NargundJohn E Houghton
May 7, 2009·Apoptosis : an International Journal on Programmed Cell Death·Young-Ok SonJeong-Chae Lee
Aug 24, 2011·Biochemistry Research International·Elena A Belyaeva, Nils-Erik L Saris
Apr 16, 2010·Canadian Journal of Physiology and Pharmacology·Ying Liu, Douglas M Templeton
Apr 3, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ann CuypersKaren Smeets
Sep 30, 2006·Cell Death and Differentiation·O FeraudG Kroemer
Sep 16, 2015·International Journal of Molecular Sciences·Tomasz OlszowskiDariusz Chlubek
Dec 31, 2008·Mutation Research·Rodrigo FrancoMihalis I Panayiotidis
Nov 18, 2008·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Suresh Vir Singh Rana
Oct 22, 2008·Survey of Ophthalmology·M MozaffariehJ Flammer
Aug 19, 2008·Free Radical Biology & Medicine·Melissa D LairdKrishnan M Dhandapani
Jul 16, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mojgan Ghavam BaigiDenyse Bagrel
May 29, 2008·Journal of Cellular Physiology·Ying Liu, Douglas M Templeton
Feb 9, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ji-Yeon YuJeong-Chae Lee
Nov 30, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A Hernández-GarcíaA J García-Fernández
Feb 16, 2012·Biochimie·Asma Kassab, Agnieszka Piwowar
Sep 14, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ming HaoHongyu Kuang
Jul 1, 2015·The Journal of Biological Chemistry·Mercè Garcia-BelinchónVictor J Yuste
Mar 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Malavika S GiriLuis J Montaner
Jan 7, 2021·Environmental Science and Pollution Research International·Burcu Yuksel
Oct 12, 2010·Journal of Cell Science·D Lorena FrancoM Angela Nieto
May 7, 2021·Cell Death and Differentiation·Pucheng MeiJixi Li

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