Regulation of aquaporin-2 in the kidney: A molecular mechanism of body-water homeostasis

Kidney Research and Clinical Practice
Tae-Hwan KwonSøren Nielsen

Abstract

The kidneys play a key role in the homeostasis of body water and electrolyte balance. Aquaporin-2 (AQP2) is the vasopressin-regulated water-channel protein expressed at the connecting tubule and collecting duct, and plays a key role in urine concentration and body-water homeostasis through short-term and long-term regulation of collecting duct water permeability. The signaling transduction pathways resulting in the AQP2 trafficking to the apical plasma membrane of the collecting duct principal cells, including AQP2 phosphorylation, RhoA phosphorylation, actin depolymerization, and calcium mobilization, and the changes of AQP2 abundance in water-balance disorders have been extensively studied. Dysregulation of AQP2 has been shown to be importantly associated with a number of clinical conditions characterized by body-water balance disturbances, including hereditary nephrogenic diabetes insipidus (NDI), lithium-induced NDI, electrolytes disturbance, acute and chronic renal failure, ureteral obstruction, nephrotic syndrome, congestive heart failure, and hepatic cirrhosis. Recent studies exploiting omics technology further demonstrated the comprehensive vasopressin signaling pathways in the collecting ducts. Taken together, these st...Continue Reading

Citations

Oct 29, 2014·Journal of the American Society of Nephrology : JASN·Yu Jin JungWon Kim
Jun 26, 2015·American Journal of Physiology. Renal Physiology·Sua KimGheun-Ho Kim
Oct 14, 2016·American Journal of Physiology. Renal Physiology·Mi Suk LeeTae-Hwan Kwon
Feb 5, 2015·American Journal of Physiology. Renal Physiology·Hyo-Jung ChoiTae-Hwan Kwon
Feb 5, 2015·American Journal of Physiology. Renal Physiology·Jae-Eun KimTae-Hwan Kwon
Feb 1, 2020·The Journal of International Medical Research·Shao OuyangChangcheng Lei
Jul 15, 2016·International Journal of Molecular Sciences·Xiao-Yan ZhangYou-Fei Guan
Mar 17, 2017·The Korean Journal of Internal Medicine·Sejoong KimJin Suk Han
Nov 16, 2018·Journal of Molecular Histology·Nur Siti Khadijah RamliNaguib Salleh
May 3, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ji HuangZhihong Yang
May 9, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Sheung-Fat KoJui-Wei Lin
Aug 5, 2015·Electrolyte & Blood Pressure : E & BP·Eui-Jung Park, Tae-Hwan Kwon
May 26, 2018·Neurourology and Urodynamics·Yosuke MorizawaKiyohide Fujimoto
Nov 29, 2017·International Journal of Sport Nutrition and Exercise Metabolism·Reid RealeLouise M Burke
May 17, 2018·American Journal of Physiology. Renal Physiology·Eric H J VerschurenFrancisco J Arjona
Jan 10, 2019·American Journal of Physiology. Renal Physiology·Ingrid F Dos SantosHassane Amlal
May 16, 2014·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Michal K OklinskiTae-Hwan Kwon
Jan 14, 2021·Scientific Reports·Michele CelestinoCarla Mucignat-Caretta
Feb 19, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Fatih Mehmet KandemirMuhammet Bahaeddin Dortbudak
Apr 6, 2021·Platelets·Ejaife O Agbani, Alastair W Poole
May 29, 2021·Canadian Journal of Physiology and Pharmacology·Anabel Brandoni, Adriana M Torres
Jun 29, 2021·American Journal of Physiology. Renal Physiology·Chen-Chung Steven LiuDennis Brown
Jun 18, 2019·The Journal of Physical Chemistry. B·Nikhil MaroliKadirvelu Krishna
Sep 10, 2021·Brain : a Journal of Neurology·Mootaz M SalmanRoslyn M Bill

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Methods Mentioned

BETA
ubiquitination
electron microscopy
GTPase

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