PMID: 9658336Jul 11, 1998Paper

Regulation of aromatase, 5 alpha- and 5 beta-reductase in primary cell cultures of developing zebra finch telencephalon

Journal of Neurobiology
F W FrekingB A Schlinger

Abstract

Sex steroids act on the developing and adult telencephalon of songbirds to organize and activate the neural circuits required for the learning and production of song. Presumably, the availability of active androgens and estrogens to steroid-sensitive neural circuits controlling song is modulated by the local expression of androgen-metabolizing enzymes. Two enzymes, 5 alpha- and 5 beta-reductase, are expressed widely in the songbird telencephalon, as they are in the telencephalons of other avian species. These enzymes convert circulating testosterone (T) into the active and inactive metabolites, 5 alpha- and 5 beta-dihydrotestosterone (DHT), respectively. A third enzyme, aromatase, converts T into estradiol (E2) and is expressed at unusually high levels in several regions of the songbird telencephalon. In many tissues, including the brain, the regulation of expression of one or more of these enzymes can be a critical feature of their ability to control the production of active sex steroids. We have used primary cell cultures to examine factors that might regulate the expression of these enzymes in developing zebra finch telencephalon. Cultures were treated for 0-72 h with sex steroids (T, E2, 5 alpha-DHT, and 5 beta-DHT) or with...Continue Reading

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Citations

Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Luke Remage-HealeyBarney A Schlinger
Apr 3, 2010·BMC Neuroscience·Sarah E London, David F Clayton
Jun 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Manfred Gahr
Nov 5, 2010·Endocrinology·J W GatsonJ G Wigginton
Mar 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Liisa A Tremere, Raphael Pinaud
Jan 26, 2007·Neuroscience and Biobehavioral Reviews·L Z GaramszegiP Surai
Aug 19, 2009·General and Comparative Endocrinology·Valérie S LangloisVance L Trudeau
Aug 21, 2010·Journal of Neurochemistry·Devaleena S PradhanKiran K Soma

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