PMID: 7010315Jan 24, 1981Paper

Regulation of aromatic amino acid transport by tRNA: role of 2-methylthio-N6-(delta2-isopentenyl)-adenosine

Nucleic Acids Research
M Buck, E Griffiths

Abstract

E. coli growing rapidly in media where ferric iron is not freely available contain a population of specifically undermodified tRNAs. These tRNAs contain isopentenyl adenosine instead of the usual methylthioisopentenyl adenosine adjacent to the 3' end of the anticodon. Iron restricted E. coli also show an enhanced capacity to transport aromatic amino acids into the cell. Our work shows that undermodified tRNAs for phe, tyr and trp can function as positive regulatory elements of the aromatic amino acid transport system in E. coli. This iron related metabolic control, mediated through a specific post-transcriptional modification of the tRNAs, may be an important mechanism for adapting E. coli for growth in an iron restricted environment.

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Citations

Jan 1, 1984·Molecular & General Genetics : MGG·T G Hagervall, G R Björk
Nov 1, 1986·Molecular & General Genetics : MGG·L A Kirsebom, L A Isaksson
Jan 1, 1991·Biology of Metals·E Griffiths
Nov 1, 1993·FEMS Microbiology Reviews·K G Wooldridge, P H Williams
Jan 1, 1994·Biochimie·B C PerssonG R Björk
Jan 30, 2004·Trends in Genetics : TIG·Manuel A S SantosMick F Tuite
Jun 11, 1981·Nucleic Acids Research·B D McLennanE Griffiths
Feb 13, 2001·Journal of Bacteriology·J ZhaoM E Winkler
Jan 1, 1988·Critical Reviews in Microbiology·S M Payne
Jul 29, 1983·Biochemical and Biophysical Research Communications·M L WoodsworthJ S Lee
Mar 10, 2017·RNA Biology·Ulrich SchweizerNoelia Fradejas-Villar
May 1, 2014·EcoSal Plus·Glenn R Björk, Tord G Hagervall
Apr 1, 1985·Journal of Bacteriology·M G Haygood, K H Nealson
Nov 1, 2005·EcoSal Plus·Glenn R Björk, Tord G Hagervall
Dec 5, 2018·Biochemistry·Leticia Pollo-Oliveira, Valérie de Crécy-Lagard

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